2018, Number 4
Rev Clin Esc Med 2018; 8 (4)
Hiperpigmentación Cutánea inducida por Fenotiazinas
Piccolo JL, Chaves LM
Language: Spanish
References: 9
Page: 1-4
PDF size: 388.69 Kb.
ABSTRACT
Chlorpromazine is an antipsychotic that has been been used since the 1950s. The development of a blue-gray pigmentation as a side effect induced by phototoxicity has been described. Fluphenazine is a product derived from phenothiazides that appears to be up to 40 times more potent than chlorpromazine.This case is about a 55 year old patient diagnosed with undifferentiated schizophrenia who is undergoing prolonged treatment with these medications. She presented to our service with a blue-gray hyperpigmentation in exposed areas and a striking corneal pigmentation. Other causes were ruled out.
REFERENCES
9.McClanahan W, Harris J, Knobloch W, Tredici L, Udasco, R. Ocular Manifestations of Chronic Phrnothiazine Derivative Administration. Arch Ophtal. 1966 Mar;75:319-325. 10.Benning T, McCormack K, Ingram P, Kaplan D, Shelburne, J. Microprobe Analysis of Chlorpromazine Pigmentation. Arch Dermatol 1988 Oct;124(10):1541-1544.