Trujillo AY, Arce BS, Viguera R, Martínez MI, White MV

Language: Spanish
References: 0
Page: 53-57
PDF size: 214.47 Kb.

ABSTRACT

Objective: To describe the characteristics of the major polymorphic and complex histocompatibility system described in humans.
Development: The major histocompatibility complex in humans, known as HLA or human leukocyte antigens, was discovered in 1958 by French scientist and Nobel Prize laureate Jean Dausset, who detects the presence of antileukocytic antibodies in the serum of multiparous women or polytransfused patients. directed against the molecules present in the cell membrane of human leukocytes. The HLA system is located on the short arm of the 6th. chromosome pair where the histocompatibility genes that encode the HLA class I molecules and the HLA class II molecules, located on the surface of almost all the nucleated cells of the human body. Each human being has a seal that gives it a specific antigenic personality, which distinguishes it from almost all other individuals of the same species.
Conclusions: The major histocompatibility complex has had an evolution since its discovery that allows the discrimination of the own and the foreign of each individual.