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ISSN 2683-1678 (Print)
Órgano Oficial de la Sociedad
Latinoamericana de lnfectología Pediátrica.
Órgano de la Asociación Mexicana de
Infectología Pediátrica, A.C.
Órgano difusor de la Sociedad Española
de lnfectología

2018, Number 1

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Rev Latin Infect Pediatr 2018; 31 (1)

Infections in patients undergoing hematopoietic progenitor cell transplantation

Otero MFJ, Ordoñez OJ, Arias GE

Language: Spanish
References: 37
Page: 22-31
PDF size: 256.43 Kb.


ABSTRACT

Hematopoietic progenitor cell transplantation (HPCT) is a useful therapy in the treatment of cancer, primary immunodeficiencies, aplastic anemia, hemoglobinopathies, genetic diseases and innate errors of metabolism. In the last few years, a disease response to transplantation of 50-90% of the cases according to pathology has occurred; however, this group of patients presents complications that can be life-threatening or deteriorate their quality of life. In particular, HPCT receptors are highly susceptible to infections, which represent a significant cause of morbidity and mortality. The degree of susceptibility to infection varies depending on the type of HPCT (autologous versus allogeneic, related versus unrelated) and when the patient is post HPCT. The periods of greatest post HPCT immunosuppression are two: during the neutropenia period, and in case of graft-versus-host disease. Therefore, the implementation of different strategies for prevention, early diagnosis and appropriate treatment has demonstrated impact on the prognosis of patients. This publication details the infectious agents (bacterial, viral, fungal and parasitic), clinical infectious syndromes, their treatment and prevention measures.


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