medigraphic.com
Colegio de Medicina Interna de México.

2018, Number 4

<< Back Next >>

Med Int Mex 2018; 34 (4)

Shark cartilage: another oncological panacea

Murillo-Domínguez G

Language: Spanish
References: 34
Page: 614-618
PDF size: 248.85 Kb.


ABSTRACT

Cancer is the third cause of death after cardiovascular diseases and diabetes mellitus. In the face of such a devastating epidemiological panorama, it is expected that a multitude of non-conventional, biological and non-biological “curative” therapies will emerge. Among the biological therapies is the shark cartilage, whose defenders of its use are based on the false premise that “sharks do not have cancer”, and when confronted, they claim conspiracy theories. Although the presence of an inhibitory factor of angiogenesis in the product has been demonstrated, clinical trials have not been conclusive as to a net beneficial effect in oncological patients. But the popular marketing of the substance is a business of several million dollars a year. It is prudent that doctors have knowledge, including possible side effects, to provide information to patients.


REFERENCES

  1. Finkelstein JB. Sharks do get cancer: few surprises in cartilage research. J Natl Cancer Inst 2005 Nov. 2;97(21):1562-3.

  2. Granados GM, Arrieta ROG, Hinojosa GJ. Prefacio, en: Granados GM, Arrieta ROG, Hinojosa GJ. Tratamiento del cáncer. Oncología médica, quirúrgica y radioterapia. Instituto Nacional de Cancerología. México: El Manual Moderno, 2016:XIII.

  3. Granados GM, Arrieta ROG, Mohar BA. Epidemiología descriptiva del cáncer. Cáncer en el mundo. Cáncer en México, en: Granados GM, Arrieta ROG, Hinojosa GJ. Tratamiento del cáncer. Oncología médica, quirúrgica y radioterapia. Instituto Nacional de Cancerología. México: El Manual Moderno, 2016:6-7.

  4. Estévez BM, Ortega MR, de Jongh DL, Campos PR. Cartílago de tiburón: acciones biológicas, empleo y perspectivas. Rev Cubana Invest Bioméd 2001 jul-sept;20(3):213-22.

  5. Ulbricht CE. Complementary, Alternative, and Integrative Therapies in Cancer Care. Biologically Based Therapies Used for Cancer Treatment and Secondary Prevention, en: DeVita VT Jr., Lawrence TS, Rosenberg SA. DeVita, Hellman, and Rosenberg’s Cancer. Principles & Practice of Oncology. Wolters Kluwer Health, Philadelphia 2015:2166-2172.

  6. Strohecker J (exec. dir.). Cancer. Laetrile, en: Alternative Medicine. The Definitive Guide. The Burton Goldberg Group. Future Medicine Publishing, Inc., Puyallup, Washington, 1994;575-576.

  7. Hall AH, Linden CH, Kulig KW, Rumack BH. Cyanide poisoning from laetrile ingestion: role of nitrite therapy. Pediatrics 1986 Aug;78(2):269-272.

  8. Gómez JA, Iriberri A. Éstos son los seis embaucadores que prometen “un mundo sin cáncer”. El Español 2018 ene. 13 (disponible en: https://www.elespanol.com/ciencia/ salud/20180113/embaucadores-prometen-mundo-sincancer/ 276723389_0.html) (consultado el 16-02-2018).

  9. Éstos son los seis embaucadores que prometen “un mundo sin cáncer”. Boletín electrónico de información sobre el fenómeno de las sectas y la nueva religiosidad. Red Iberoamericana de Estudio de las Sectas 2018 ene. 25;(554):No.2 (disponible en: http://info-ries.blogspot. mx/) (consultado el 16-02-2018)

  10. Selachimorpha, en: Wikipedia (disponible en: https:// es.wikipedia.org/wiki/Selachimorpha) (consultado el 16-02-2018).

  11. Lane WI, Comac L. Sharks don’t get cancer. How shark cartilage could save your life. Avery Publishing, Garden City Park, NY, 1992 (Lane WI, Comac L. Sharks Still Don’t Get Cancer: The Continuing Story of Shark Cartilage Therapy. Avery Publishing, Garden City Park, NY, 1996).

  12. Strohecker J (exec. dir.). Cancer. Shark Cartilage, en: Alternative Medicine…, op. cit., pág. 575.

  13. Wellings SR. Neoplasia and primitive vertebrate phylogeny: echinoderms, prevertebrates, and fishes--A review. Natl Cancer Inst Monogr 1969 Jul.;31:59-128.

  14. Ostrander GK, Cheng KC, Wolf JC, Wolfe MJ. Shark cartilage, cancer and the growing threat of pseudoscience. Cancer Res 2004 Dec. 1;64(23):8485-8491.

  15. Alifrangis C, Stebbi J. Shark cartilage: has the popularisation of science failed? Lancet Oncol 2012 Jan;13(1):22.

  16. NIH. Instituto Nacional del Cáncer. Cartílago (bovino y de tiburón) (PDQ®)–Versión para profesionales de salud 2017 jul. 10 (disponible en: https://www.cancer.gov/espanol/ cancer/tratamiento/mca/pro/cartilago-pdq#section/all) (consultado el 16-02-2018).

  17. Prudden JF. The treatment of human cancer with agents prepared from bovine cartilage. J Biol Response Mod 1985;4(6):551-84.

  18. Romano CF, Lipton A, Harvey HA, et. al. A phase II study of Catrix-S in solid tumors. J Biol Response Mod 1985;4(6):585-9.

  19. Puccio C, Mittelman A, Chun P, et. al. Treatment of metastatic renal cell carcinoma with Catrix. Proceed Am Soc Clin Oncol 1994;13:A-769, 246.

  20. Miller DR, Anderson GT, Stark JJ, et al. Phase I/II trial of the safety and efficacy of shark cartilage in the treatment of advanced cancer. J Clin Oncol 1998;16(11):3649-55.

  21. Leitner SP, Rothkopf MM, Haverstick L, et al. Two phase II studies of oral dry shark cartilage powder (SCP) with either metastatic breast or prostate cancer refractory to standard treatment. Proceed Am Soc Clin Oncol 1998;17:A-240.

  22. Rosenbluth RJ, Jennis AA, Cantwell S, et al. Oral shark cartilage in the treatment of patients with advanced primary brain tumors. Proceed Am Soc Clin Oncol 1999;18:A-554.

  23. Jungi WF. Dangerous nutrition. Support Care Cancer 20013;11(4):197-8.

  24. Lagman R, Walsh D. Dangerous nutrition? Calcium, vitamin D, and shark cartilage nutritional supplements and cancer-related hypercalcemia. Support Care Cancer 2003;11:232-235.

  25. Ashar B, Vargo E. Shark cartilage-induced hepatitis. Ann Intern Med 1996;125(9):780-1.

  26. Falardeau P, Champagne P, Poyet P, et. al. Neovastat, a naturally occurring multifunctional antiangiogenic drug, in phase III clinical trials. Semin Oncol 2001;28(6):620-5.

  27. Basulto MJ. El cartílago de tiburón no solo es inútil contra el cáncer, es algo más. El País 2018 feb. 12 (disponible en: https://elpais.com/elpais/2018/02/06/ciencia/ 1517916027_823830.html) (consultado el 16-02-2018)

  28. Mondo K, Broc GW, Murch SJ, Guangliang L, Yong C et al. Environmental neurotoxins β-N-methylamino-l-alanine (BMAA) and mercury in shark cartilage dietary supplements. Food Chem Toxicol 2014 Jan 8;70:26-32.

  29. Jacobs JJ. Métodos alternativos y sin demostrar para el tratamiento del cáncer, en: DeVita VT, Hellman S, Rosenberg SA. Cáncer. Principios y práctica de Oncología. Edit. Médica Panamericana, Madrid-Arán Ediciones, Madrid, 2000;2:2993-3001.

  30. Lu C, Lee JJ, Komaki R, Herbst RS, Feng L, Evans WK, et al. Chemoradiotherapy with or without AE-941 in stage III non-small cell lung cancer: a randomized phase III trial. J Natl Cancer Inst 2010 Jun;102(12):859-65.

  31. Loprinzi CL, Levitt R, Barton DL, Sloan JA, Atherton PJ, Smith DJ et al. North Central Cancer Treatment Group. Evaluation of shark cartilage in patients with advanced cancer: a North Central Cancer Treatment Group trial. Cancer 2005;104(1):176.

  32. Merly L, Smith SL. Pro-inflammatory properties of shark cartilage supplement. Immunopharmacol Immunotoxicol 2015 Apr;37(2):140-7.

  33. Jeevithan E, Bao B, Zhang JY, Hong ST, Wu WH. Purification, characterization and antioxidant properties of low molecular weight collagenous polypeptide (37 kDa) prepared from whale shark cartilage (Rhincodon typus). J Food Science and Technology-Mysore 2015 Oct.;52(10):6312-6322.

  34. Trivedi R, Salvo MC. Utilization and safety of common over-the-counter dietary/nutritional supplements, herbal agents, and homeopathic compounds for disease prevention. Med Clin N Am 2016 Sept. 1;100(5):1089-1099.




2020     |     www.medigraphic.com