2018, Number 3
Bacteremias en HIV-patients in a third level hospital in Colombia, 2014-2016
Language: Spanish
References: 17
Page: 366-372
PDF size: 459.09 Kb.
ABSTRACT
Background: Bloodstream infections are a growing problem and currently a threat to public health. Bacteremia accounts for 15% of all nosocomial infections. In patients with HIV, the degree of immunosuppression continues to be the most important risk factor.Objective: To describe the clinical microbiological and epidemiological characteristics of patients with HIV infection and bacteremia.
Material and Method: A descriptive observational study with patients over 14 years of age with positive blood cultures from the internal medicine service of the Hospital Universitario de Santander, Colombia, between 2014 and 2016, with HIV infection and who met the CDC criteria for torrent infection.
Results: We reviewed 450 records, 44 patients with confirmed diagnosis. 59% were men; the mean age was 42 years. The median of CD4+ T lymphocytes count was 29 cells/mm3, 55.8% had no antiretroviral treatment because they were new diagnoses. The mortality rate was 31.8%. The PITT severity index was classified as mild at 68.1%. The most frequent group of bacteria was the Enterobacteriaceae including K. pneumoniae with 25%. The percentage of resistant germs (E. coli and K. pneumoniae BLEE, P. aeuruginosa MDR, A. baumanii MDR and S. aureus MR) was 26.9%.
Conclusions: The group of patients with HIV in our institution is superior to other series. One in four patients with HIV infection and bacteremia have resistant microorganism.
REFERENCES
INSIGHTSTART Study Group, Lundgren JD, Babiker AG, Gordin F, Emery S, Grund B, Sharma S, Avihingsanon A, Cooper DA, F€atkenheuer G, Llibre JM, et al. Initiation of antiretroviral therapy in early asymptomatic HIV infection. N Engl J Med 2015;373:795-807; PMID:26192873; http:// dx.doi.org/10.1056/NEJMoa1506816.
O’Connor J, Vjecha MJ, Phillips AN, Angus B, et al. Effect of immediate initiation of antiretroviral therapy on risk of severe bacterial infections in HIV-positive people with CD4 cell counts of more than 500 cells per μL: secondary outcome results from a randomised controlled trial. Lancet HIV 2017;4:e105-112.
Jacob ST, Pavlinac PB, Nakiyingi L, Banura P, Baeten JM, et al. Mycobacterium tuberculosis bacteremia in a cohort of HIV-infected patients hospitalized with severe sepsis in Uganda–high frequency, low clinical sand derivation of a clinical prediction score. PLoS ONE 2013;8(8):e70305. doi:10.1371/ journal.pone.0070305.
Fondo Colombiano de Enfermedades de Alto Costo. Situación actual del VIH en Colombia 2015 [Internet]. Ministerio de Salud y Protección Social. Colombia;2015. Consultado: [11/01/2018]. Disponible en: https://cuentadealtocosto. org/site/images/Publicaciones/Situacio%CC%81n%20 del%20VIH%20en%20Colombia%202015.pdf