Andrade RML, García PWF, Rodríguez AR, Davas AY

Language: Spanish
References: 0
Page: 1-6
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ABSTRACT

Introduction: celiac disease is an autoinmune enteropathy sensitive to gluten and other prolamines, with genetic basis. It generates when the patient gets in contact with those proteins present in wheat, barley and rye and causes intestinal and extraintestinal symptoms. The diagnosis of this disease has advanced from clinical criteria to immune and genetic tests in addition to intestinal biopsy.
Objective: to perform screening of blood samples by using the Cuban test called HeberFast Line^® antitransglutaminase to find out the frequency of this marker in the infant population tested in our laboratory.
Methods: fight hundred and fifty blood samples were studied to detect the presence of tissue antitransglutaminase antibodies.
Results: in our research work, 10 samples were positive (1.18 %), which agrees with the reports of the reviewed literatura. Other 75 samples (8.8 %) were not valid for the fist attempt, an event described by the test manufacturers, which can be easily solved by using the sample again and then analyzed for the second time; they changed to the caterogy of negative samples. Finally, 98.82 % of the analyzed samples were negative.
Conclusions: in the study samples, 1.18 % had tissue antitransglutaminase antibodies, so roughly 1 per 100 children may suffer from celiac disease; additionally, this test is a useful tool for an early diagnosis that is not so uncommon in our country.