Castañer MJ, Hurtado MAJ, Rodríguez BR, Montero GT, Barroso CJ, Joseph PH, De Armas GT, Herrera AM, González RO

Language: Spanish
References: 0
Page: 256-565
PDF size: 113.11 Kb.

ABSTRACT

Introduction: The histopathological diagnosis of acute tubular necrosis, usually of ischemic or nephrotoxic cause, is closely related to the development of acute renal failure.
Objective: To analyze the presence of histopathological diganosis of acute tubular necrosis in deceased autopsied and to explore the relationship with possible favoring factors.
Method: Retrospective, observational study, with descriptive statistical study of the autopsies at the Central Military Hospital Dr. Luis Díaz Soto in the period from 1962 to 2015. The histopathological diagnosis of acute tubular necrosis was done and demographic, clinical and anatomopathological variables were analyzed.
Results: 843 341 discharged from hospital were recorded, of which 25 213 died (mortality rate 3.0), 18 630 autopsies were performed (autopsy rate 75.3 %). In these cases a diagnosis of acute tubular necrosis was done in 6 264 (33.6 %). Male patients and those over 45 years of age predominated. Shock (22.3 %), bronchopneumonia (16.3 %), coronary atherosclerosis (18.5 %) and pulmonary edema (11.3 %) were the main direct causes of death. Coronary atherosclerosis (18.5 %) was the main underlying cause of death.
Conclusions: There was a sustained increase in discharged patients, deaths and autopsies, as well as the histopathological diagnosis of acute tubular necrosis. Male patients predominated and those older than 45 years of age. The main direct causes of death in these were shock, bronchopneumonia and pulmonary edema. Atherosclerosis was the leading cause of death.