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2018, Number S1

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Rev Med Inst Mex Seguro Soc 2018; 56 (S1)

Relationship between bone remodeling and metabolism in the elderly

Basurto-Acevedo L, Saucedo-García R, Vázquez-Martínez A, Cruz-García M, Valle-Hernández MM, Rosales-Cruz E, Sánchez-Arenas R

Language: Spanish
References: 23
Page: 6-11
PDF size: 294.96 Kb.


ABSTRACT

Background: Recent studies have shown that osteocalcin (OC) is related to not only bone metabolism but also energy metabolism. The aim of the present study was to investigate whether OC was associated with metabolic factors and bone mineral density (BMD) in elderly men.
Methods: A cross-sectional study was done including 122 healthy men aged 60 years or older. Serum glucose, lipids, insulin, adiponectin and OC were measured and BMD was estimated using dual energy X-ray absorptiometry.
Results: 42.8% of men had metabolic syndrome (MetS). OC levels were not significantly different between men with and without MetS. OC concentrations were inversely associated with body mass index (BMI) (r = −0.226, p = 0.04), waist circumference (r = −0.261, p = 0.02), glucose (r = −0.245, p = 0.03), insulin (r = −0.235, p = 0.03), and HOMA-IR (r = −0.211, p = 0.04). In addition, OC levels were higher in patients with diminished BMD compared with those with normal BMD.
Conclusions: OC levels correlate negatively with BMI, waist circumference, glucose, insulin and HOMA-IR in elderly men, which suggests a connection between bone and energy metabolism.


REFERENCES

  1. Hauschka PV, Lian JB, Cole DE, Gundberg CM. Osteocalcin and matrix Gla protein: vitamin K-dependent proteins in bone. Physiol Rev.1989;69(3):990-1047.

  2. Karsenty G, Ferron M. The contribution of bone to whole-organism physiology. Nature. 2012;481 (7381):314-20.

  3. Ducy P. The role of osteocalcin in the endocrine cross-talk between bone remodelling and energy metabolism. Diabetologia 2011;54(6):1291-7.

  4. Lee NK, Sowa H, Hinoi E, Ferron M, Ahn JD, Confavreux C, et al. Endocrine regulation of energy metabolism by the skeleton. Cell. 2007;130(3):456-69.

  5. Zárate A, Basurto L, Saucedo R. El tejido óseo se incorpora a la constelación hormonal. Rev Med Inst Mex Seguro Soc. 2010;48(1):1-5.

  6. Saleem U, Mosley TH Jr, Kullo IJ. Serum osteocalcin is associated with measures of insulin resistance, adipokine levels, and the presence of metabolic syndrome. Arterioscler Thromb Vasc Biol. 2010;30 (7):1474-8.

  7. Tan A, Gao Y, Yang X, Zhang H, Qin X, Mo L, et al. Low serum osteocalcin level is a potential marker for metabolic syndrome: results from a Chinese male population survey. Metabolism. 2011;60(8):1186-92.

  8. Yeap BB, Chubb SA, Flicker L, McCaul KA, Ebeling PR, Beilby JP, et al. Reduced serum total osteocalcin is associated with metabolic syndrome in older men via waist circumference, hyperglycemia, and triglyceride levels. Eur J Endocrinol. 2010;163(2):265-72.

  9. Confavreux CB, Szulc P, Casey R, Varennes A, Goudable J, Chapurlat RD. Lower serum osteocalcin is associated with more severe metabolic syndrome in elderly men from the MINOS cohort. Eur J Endocrinol. 2014;171(2):275-83.

  10. Oosterwerff MM, van Schoor NM, Lips P, Eekhoff EM. Osteocalcin as a predictor of the metabolic syndrome in older persons: a population-based study. Clin Endocrinol (Oxf). 2013;78(2):242-7.

  11. Pittas AG, Harris SS, Eliades M, Stark P, Dawson- Hughes B. Association between serum osteocalcin and markers of metabolic phenotype. J Clin Endocrinol Metab. 2009;94(3):827-32.

  12. Hwang YC, Jeong IK, Ahn KJ, Chung HY. The uncarboxylated form of osteocalcin is associated with improved glucose tolerance and enhanced beta-cell function in middle-aged male subjects. Diabetes Metab Res Rev. 2009;25(8):768-72.

  13. Alberti KG, Zimmet P, Shaw J. The metabolic syndrome-- a new worldwide definition. Lancet. 2005; 366(9491):1059-62.

  14. Alberti KG, Zimmet P, Shaw J. Metabolic syndrome- -a new world-wide definition. A consensus statement from the international diabetes federation. Diabetic Medicine. 2006;23(5):469-80.

  15. Matthews DR, Rudenski AS, Burnett MA, Darling P, Turner RC. The half-life of endogenous insulin and C-peptide in man assessed by somatostatin suppression. Clin Endocrinol (Oxf). 1985; 23(1):71-9.

  16. Iki M, Tamaki J, Fujita Y, Kouda K, Yura A, Kadowaki E, et al. Serum undercarboxylated osteocalcin levels are inversely associated with glycemic status and insulin resistance in an elderly Japanese male population: Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. Osteoporos Int. 2012;23(2):761-70.

  17. Musso C, Mingote E, Durante C, Brenta G, Gurfinkiel M, Fossati MP et al. Correlación entre osteocalcina, insulinorresistencia, insulinosensibilidad y metabolismo de la glucosa en adultos mayores con síndrome metabólico. Rev Argent Endocrinol y Metab. 2015;52 (1):8-14.

  18. Kindblom JM, Ohlsson C, Ljunggren O, Karlsson MK, Tivesten A, Smith U, et al. Plasma osteocalcin is inversely related to fat mass and plasma glucose in elderly Swedish men. J Bone Miner Res 2009;24(5):785-91.

  19. Lihn AS, Pedersen SB, Richelsen B. Adiponectin: action, regulation and association to insulin sensitivity. Obes Rev. 2005;6(1):13-21.

  20. Zhang Y, Zhou P, Kimondo JW. Adiponectin and osteocalcin: relation to insulin sensitivity. Biochem Cell Biol. 2012; 90(5):613-20.

  21. Brown JP, Delmas PD, Malaval L, Edouard C, Chapuy MC, Meunier PJ. Serum bone Gla-protein: a specific marker for bone formation in postmenopausal osteoporosis. Lancet.1984;77(3):1091-3.

  22. Edelstein SL, Barrett-Connor E. Relation between body size and bone mineral density in elderly men and women. Am J Epidemiol.1993;138(3):160-9.

  23. Lindsay R, Cosman F, Herrington BS, Himmelstein S. Bone mass and body composition in normal women. J Bone Miner Res. 2001;7(1):55-63.




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