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2018, Number 2

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Rev Clin Esc Med 2018; 8 (2)

El Proteosoma, sus Inhibidores y Toxicidad Cardíaca

Rodriguez PMA, Méndez LMA

Language: Spanish
References: 35
Page: 11-21
PDF size: 414.20 Kb.


ABSTRACT

The proteasome is key for proteostasis. Treatment with proteasome inhibitors in multiple myeloma patients is the hallmark of actual guidelines, however, its therapeutic effect comes bound to toxicity. Recent advances in the understanding of the ubiquitin-proteasome system in solid tumors and neurological disorders preclude the expansion of the clinical use of the proteasome inhibitors out the haematological setting, therefore knowledge of the secondary effects, especially cardiotoxicity is essential.


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