Cruz GY

Language: Spanish
References: 0
Page: 270-287
PDF size: 654.86 Kb.

ABSTRACT

Rationale: Myocardial revascularization surgery (MRS) ameliorates the coronary risk of the patient by improving the supply of oxygenated blood to the heart muscle. It is likely that MRS affects the serum lipid variables, and hence, the atherogenic risk of the patient. Objective: To assess the changes occurring in serum lipid variables immediately after MRS. Study design: Prospective, longitudinal. Study serie: Seventy patients (Males: 74.2%; Average age: 62.1 ± 7.3 years) subjected to MRS (Extracorporeal surgery: 41.4%; Adverse clinical events: 24.3%) at the “Hermanos Ameijeiras” Cardiocenter (Havana city, Cuba) between January 2014 and October 2015 (both included). Methods: Serum values of total and fractionated cholesterol, triglycerides, and lipoprotein(a) were measured in 4 different moments of MRS. Associations between serum values of the lipid variable and occurrence of adverse clinical events (ACE) were examined. Behavior of the lipid variable after MRS was also assessed. Results: MRS significantly reduced presurgical values of the examined lipid variables. The observed reduction was independent from the occurrence of ACEs following MRS, and the MRS protocol. Hypocholesterolemia and hypertriglyceridemia (and by extension elevated VLDL) signaled those patients developing ACEs. Conclusions: MRS modifies the behavior of serum lipid variables significantly. Serum lipid variables might be considered as negative acute-phase reactants.