Morales-Ramírez F, Bertado-Cortés B, Carrera-Pineda R

Language: Spanish
References: 19
Page: 85-94
PDF size: 864.76 Kb.

ABSTRACT

Background. Primary Central Nervous System Vasculitis (VPSNC) is an heterogeneous and infrequent disease characterized for vasculitis limited to the brain and spinal cord. The diagnosis is oriented by angiography and confirmed by biopsy. The treatment of VPSNC is based on the combination of steroids and cyclophosphamide, but nevertheless, some patients are intolerant or do not have favorable response to this treatment. To our knowledge there is only two other reports ( three patients total) of VPSNC treated with Rituximab.
Case report. We document the case of a female patient, 28 years old with diagnosis of VPSNC pseudotumoral variant, angiographically negative. In consideration of refractoriness of pseudotumoral variant with first-line treatment, we decided to administer treatment with Rituximab.
Conclusions. Rituximab can be considered in a future to be a fistline treatment for VPSNC.

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