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Revista Médica Sinergia

2018, Number 02

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Revista Médica Sinergia 2018; 3 (02)

Paraquat neurotoxicity

Todorov T

Language: Spanish
References: 10
Page: 3-6
PDF size: 391.91 Kb.


ABSTRACT

Paraquat (1-1´-dimetil-4-4-bipyridylium dichloride) is widely used in Costa Rica as a herbicide and is marketed as a 20% aqueous solution (Gramoxone). Paraquat poisoning carries a high mortality rate. Severe paraquat poisoning is characterized by multiple-organ involvement, mainly the lungs, kidneys, liver. The lung is a major target organ in paraquat poisoning, and respiratory failure from acute pulmonary fibrosis is the most common cause of death. Paraquat is neurotoxic , but the neurotoxic effect of paraquat in acute intoxication in humans is not yet clear.


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