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Centro Universitario de Ciencias de la Salud de la Universidad de Guadalajara y del OPD Hospitales Civiles de Guadalajara

2005, Number s1

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Inv Salud 2005; 7 (s1)

Risk Factors in the genesis of Gallstone Disease

González HM, Bastidas RBE, Panduro CA

Language: Spanish
References: 35
Page: 71-78
PDF size: 250.82 Kb.


ABSTRACT

Cholesterol cholelithiasis is a common digestive disease, the etiology and the pathogenesis of cholesterol gallstones (GS) have not been elucidated. Family and epidemiological studies underscore the importance of genetic factors; environmental factors are likely to be as important and in complex interactions with gallstone genes. Cholelithiasis is, together with heart disease and Diabetes Mellitus, one of the most frequent diseases in industrialized countries, affects 15% of the western populations (10% males, 20% females). In Mexico, the reported prevalence of GS is 8.5% males, 20.5% females. Diet is one relevant environmental factor of GS formation, dietary risk factors are: increased caloric intake, elevated intake of cholesterol and animal fat. Age, parity, obesity and dieting with body weight lost (fast and repeated) also play a part. Vegetables, dietary fiber, coffee and alcohol intake seem to have an inverse relationship to GS. Chromosomal organization of candidate genes involved GS in the mouse have been presented as a gallstone map. The pathophysiology of cholesterol GS formation is complex due to a large number of interacting genes that regulate cholesterol homeostasis and its secretion into bile.


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