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2013, Number 2

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Med Sur 2013; 20 (2)

Bases moleculares de la preeclampsia-eclampsia

Carrillo-Esper R, Sánchez-Zúńiga MJ

Language: Spanish
References: 23
Page: 103-109
PDF size: 139.01 Kb.


ABSTRACT

Preeclampsia-eclampsia remains a major cause of worldwide pregnancy related maternal mortality. Several hypothesis have been developed to explain its presentation and development, as well as various molecular basis proposed which includes alterations in the placenta implantation and imbalance in the function of certain molecules such as relaxin, matrix metalloproteinases, endothelin, nitric oxide, angiogenic factors, oxidative stress, endothelial dysfunction and genetic factors. The aim of this study was to review current concepts related to the molecular basis of preeclampsiaeclampsia


REFERENCES

  1. Mutter WP, Karumachi SA. Molecular Mechanisms of preeclampsia. Microvasc Res 2008; 75: 1-8.

  2. Irani RA, Xia Y. The functional role of the renin-angiotensin system in pregnancy and preeclampsia. Placenta 2008; 29: 763-71.

  3. Grill s, Rusterholz C, Zanetti-Dällenbach R, Tercanli S, Holzgreve W, Hahn S, Lapaire O. Potential markers of preeclampsia- a review. Reproductive Biology and Endocrinology 2009; 7: 70-84.

  4. Bonney EA. Preeclampsia: a view through the danger model. J Reprod Immunol 2007; 76: 68-74.

  5. Carty DM, Delles C, Dominiczak AF. Novel biomarker for predicting preeclampsia. Trends Cardiovasc Med 2008; 18: 186-94.

  6. van Rijn BB, Franx A, Steegers EA, de Groot CJ, Bertina RM, Pasterkamp G, Voorbij HA, et al. Maternal TLR4 and NOD2 gene variants, proinflammatory phenotype and susceptibility to early onset preeclampsia and HELLP syndrome. PLos ONE 2008; 3: 1-9.

  7. Solomon CG, Seely EW. Hypertension in pregnancy. Endocrinol Metab Clin N Am 2006; 35: 157-71.

  8. Gregg AR. Hypertension in pregnancy. Obstet Gynecol Clin N Am 2004; 31: 223-41.

  9. Henry CS, Biedermann SA, Campbell MF, Guntupalli JS. Spectrum of hypertensives emergencies in pregnancy. Crit Care Clin 2004; 20: 697-712.

  10. Aagaard TK, Belfort MA. Eclampsia: morbidity, mortality and management. Clin Obstet Gynecol 2005; 48: 12-23.

  11. Harrison GA, Humphrey KE, Jones N, Badenhop R, Guo G, Elakis G, Kaye JA, et al. A genome-wide linkage study of preeclampsia- eclampsia reveals evidence for a candidate region non 4q. Am J Human Genet 1997; 60: 1158-67.

  12. Chambers JC, Fusi L, Malik IS, Haskard DO, De Swiet M, Kooner JS. Association of maternal endothelial dysfunction with preeclampsia. JAMA 2001; 1607-12.

  13. Carr DB, Epplein M, Jonson CO. A sister’s risk: family history as a predictor of preeclampsia. Am J Obstet Gynecol 2005; 193: 965- 72.

  14. Levine RJ, Maynard SE, Qian C, Lim KH, England LJ, Yu KF, Schisterman EF, et al. Circulating angiogenic factors and risk of preeclampsia. N Engl J Med 2004; 350: 672-83.

  15. Kaufmann P, Black S, Huppertz B. Endovascular trophoblast invasion: implications for the pathogenesis of intrauterine growth retardation and preeclampsia. Biol Reprod 2003; 69: 1-7.

  16. Heyl W, Handt S, Reister F, Gehlen J, Mittermayer C, Rath W. The role of soluble adhesion molecules in evaluating endothelial cell activation in preeclampsia. Am J Obstet Gynecol 1999; 180: 68-72.

  17. González-Quintero VH, Smarkusky LP, Jiménez JJ, Mauro LM, Jy W, Hortsman LL, O’Sullivan MJ, et al. Elevated plasma endothelial microparticles: preeclampsia versus gestational hypertension. Am J Obstet Gynecol 2004; 191: 1418-24.

  18. Davison JM, Homuth V, Jeyabalan A, Conrad KP, Karumanchi SA, Quaggin S, Dechend R, et al. New aspects in the pathophysiology of preeclampsia. J Am Soc Nephrol 2004; 15: 2440-8.

  19. Wang Y, Gu Y, Lucas MJ. Expression of thrombin receptors in endothelial cells and neutrophils from normal and preeclamptic pregnancies. J Clin Endocrinol Metabolism 2002; 87: 167-73.

  20. Fawaz A, Raj R, Ma’asoumah M. Maternal cytokine production patterns in women with preeclampsia. Am J Reproduc Immunol 2005; 54: 30-7.

  21. Wang Y, Gu Y, Zhang Y, Lewis DF. Evidence of endothelial dysfunction in preeclampsia: decreased endothelial nitric oxide synthase expression is associated with increased cell permeability in endothelial cell from preeclampsia. Am J Obstet Gynecol 2004; 190: 817-24.

  22. Steingrub JS. Pregnancy-associated severe liver dysfunction. Crit Care Clin 2004; 20: 763-76.

  23. Yoveg Y, Xenakis EM, Langer O. The association between preeclampsia and the severity of gestational diabetes: the impact of glycemic control. Am J Obstet Gynecol 2004; 191: 1655-60.




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