Herrera BAJ, Ruiz CHJ, Zumeta DMT

Language: Spanish
References: 0
Page: 260-270
PDF size: 200.62 Kb.

ABSTRACT

Introduction: The extracellular matrix (ECM) forms the medium that surrounds the cells, influencing their functions. The MEC participates in functions such as: proliferation, differentiation, adhesion, migration, cell survival; diffusion of nutrients, growth factors, signal transduction, among others and is made up of several components, among which are the collagen. The present review aims to address some characteristics of the super family of collagen. Development: The collagen constitute a super family of proteins that are characterized by three polypeptide chains arranged in triple helix and a repetitive sequence of three amino acids: Gly XY called collagenous domain; where one amino acid is glycine and the other two, in many cases are proline and hiroxyproline. Some collagen have non-collagenous domains and interruptions of the triple helix. So far, 28 types of collagen have been described with specific locations and functions, which are grouped into subfamilies according to their structural and functional characteristics. These subfamilies are: collagen forming banded fibers, which are associated with these fibers, which are arranged forming sheets, which form anchoring fibrils, which are arranged associated with the plasma membrane and multiplexins. Conclusions: During the last decades the molecular characteristics and functions of the collagen have been determined, as well as the diseases that are caused by mutations of the genes that encode them; such is the case of Alport syndrome, epidermolysis bulosa, Ehlers-Danlos syndrome, among others.