2018, Number 2
Next >>
Ann Hepatol 2018; 17 (2)
Natural Extracts as Modifiers of Intracellular Lipid Handling
Margherita MR, Pingitore P
Language: English
References: 10
Page: 180-181
PDF size: 117.51 Kb.
Text Extraction
Non-alcoholic fatty liver disease (NAFLD) is a spectrum
of conditions ranging from simple liver fat accumulation
to inflammation and fibrosis, and ultimately to
cirrhosis and liver cancer. NAFLD prevalence is increasing
worldwide and it is expected to be the main reason for
liver transplantation in the next decade. Although NAFLD
in its early stages can be resolved by dietary modifications
and lifestyle changes (weight loss), liver transplantation is
the only existing treatment for the later stages of the disease.
There is no drug approved as a specific treatment
against NAFLD although vitamin E has shown to reduce
NAFLD with a modest effect. Based on antioxidant effects,
natural compounds including resveratrol, quercetin
and anthocyanin have been proposed as treatment against
NAFLD.
REFERENCES
Hardy T, Anstee QM, Day CP. Nonalcoholic fatty liver disease: new treatments. Curr Opin Gastroenterol 2015; 31: 175-83.
El Hadi H, Vettor R, Rossato M. Vitamin E as a Treatment for Nonalcoholic Fatty Liver Disease: Reality or Myth? Antioxidants (Basel) 2018; 7.
Ferramosca A, Di Giacomo M, Zara V. Antioxidant dietary approach in treatment of fatty liver: New insights and updates. World J Gastroenterol 2017; 23: 4146-57.
Romeo S, Kozlitina J, Xing C, Pertsemlidis A, Cox D, Pennacchio LA, Boerwinkle E, et al. Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease. Nat Genet 2008; 40, 1461-5.
Sookoian S, Pirola CJ. Meta-analysis of the influence of I148M variant of patatin-like phospholipase domain containing 3 gene (PNPLA3) on the susceptibility and histological severity of nonalcoholic fatty liver disease. Hepatology 2011; 53: 1883-94.
He S, Mc Phaul C, Li JZ, Garuti R, Kinch L, Grishin NV, CohenJC, Hobbs HH. A sequence variation (I148M) in PNPLA3 associated with nonalcoholic fatty liver disease disrupts triglyceride hydrolysis. J Biol Chem 2010; 285: 6706-15.
Pirazzi C, Adiels M, Burza MA, Mancina RM, Levin M, Ståhlman M, Taskinen MR, et al. Patatin-like phospholipase domain- containing 3 (PNPLA3) I148M (rs738409) affects hepatic VLDL secretion in humans and in vitro. J Hepatol 2012; 57: 1276-82.
Pirazzi C, Valenti L, Motta BM, Pingitore P, Hedfalk K, Mancina RM, Burza MA, et al. PNPLA3 has retinyl-palmitate lipase activity in human hepatic stellate cells. Hum Mol Genet 2014; 23: 4077-85.
Pingitore P, Dongiovanni P, Motta BM, Meroni M, Lepore SM, Mancina RM, Pelusi S, et al. PNPLA3 overexpression results in reduction of proteins predisposing to fibrosis. Hum Mol Genet 2016; 25(23): 5212-22.
Mancina RM, Matikainen N, Maglio C, Söderlund S, Lundbom N, Hakkarainen A., Rametta R, et al. Paradoxical Dissociation Between Hepatic Fat Content and De Novo Lipogenesis Due to PNPLA3 Sequence Variant. J Clin Endocrinol Metab 2015; 100: E821-E825.
Full text