Mercado ÁF, Méndez MA, Barragán MS, Guzmán VE, Sánchez GSA

Language: Spanish
References: 16
Page: 22-26
PDF size: 164.08 Kb.

ABSTRACT

We present a clinical case of a female patient with a diffuse large B-cell non-Hodgkin lymphoma of the brain, with clinical data hemolysis and transfusion requirements, anemic syndrome, with positive irregular antibody screening. Immunohematologic basic tests were used for the identification of the specificity of these antibodies, finding a mixture of anti-E, anti-Jk^b, anti-Fy^a and through a directed panel with triple negative cells identified an anti-Js^b, which has been very infrequently reported and which has an uncertain clinical significance. We describe the diagnostic and therapeutic difficulties in immunohematology of these patients with transfusional requirements, and the need of having in Mexico available reagents for the proper identification of high incidence antigens in Hispanic population as well as the implementation of molecular biology techniques for diagnosis in immunohematology.

REFERENCES

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8. Yuan S, Ewing NP, Bailey D, Salvador M, Wang S. Transfusion of multiple units of Js (b+) red blood cells in the presence of anti-Jsb in a patient with sickle B-thalassemia disease and review of literature. Immunohematology. 2007; 23 (2): 75-80.

9. Westhoff CM, Reid ME. Review: the Kell, Duffy, and Kidd blood group system. Immunohematology. 2004; 20 (1): 37-49.

10. Lee S. The value of DNA analysis for antigens of the Kell and Kx blood group systems. Transfusion. 2007; 47 (Suppl. 1): 32S-39S.

11. Zalpuri S, Zwaginga JJ, le Cessie S, Elshuis J, Schonewille H, van der Bom JG. Red blood cell alloimmunization and number of red blood cell transfusions. Vox Sang. 2012; 102 (2): 144-149.

12. Shonewille H, de Vries R, Brand A. Alloimmune response after additional red blood cell antigen challenge in immunized hematooncology patients. Transfusion. 2009; 49 (3): 453-457.

13. Schonewille H, Doxiadis II, Levering WH, Roelen DL, Claas FH, Brand A. HLA-DRB1 associations in individuals with single and multiple clinically relevant red blood cell antibodies. Transfusion. 2014; 54 (8): 1971-1980.

14. Sapatnekar S, Figueroa PI. How do we use molecular red blood cell antigen typing to supplement pretransfusion testing? Transfusion. 2014; 54 (6): 1452-1458. doi: 10.1111/trf.12623

15. Blue-Hnidy DE, Parker C, Slayten JS et al. Successful transfusion of Js(b+) red blood cells incompatible for anti-Jsb alloantibody. Transfusion. 2004; 44 (Suppl. ): 127A.

16. Yuan S, Ewing NP, Bailey D, Salvador M, Wang S. Transfusion of multiple units of Js (b+) red blood cells in the presence of anti-Jsb in a patient with sickle B-thalassemia disease and review of literature. Immunohematology. 2007; 23 (2): 75-80.