medigraphic.com
ISSN 1561-3119 (Electronic)

2017, Number S1

<< Back Next >>

Rev Cubana Pediatr 2017; 89 (S1)

Streptococcus pneumoniae serotypes responsible for invasive disease affecting Cuban children

Toraño PG, Suárez AD, Abreu CM, Barreto NB, Toledo RE, Linares PN

Language: Spanish
References: 20
Page: 172-180
PDF size: 111.68 Kb.


ABSTRACT

Introduction: Streptococcus pneumoniae is a significant cause of morbidity and mortality worldwide mainly in children younger than 5 years. The pneumococcal vaccination has not been yet put into practice in Cuba; however, since 2014 a protocol of sentinel surveillance of the invasive pneumococcal disease in children aged 5 years or less is being implemented to lay the foundations for the evaluation of the impact of this vaccine.
Objectives: to report on the S. pneumoniae serotypes responsible for the invasive pneumococcal disease in the Cuban pediatric population and to assess the contribution of this protocol to surveillance.
Methods: the serotypes of all the invasive pediatric isolates and the recovered ones of acute otitis media were determined by the national laboratory of pneumococcal reference of "Pedro Kourí" Institute of Tropical Medicine from 2013 to 2015. The capsular swelling method was used with the Penumotest reagent set.
Results: one hundred and forty one invasive isolates were reported at pediatric ages. The isolates causing pneumonia predominated (76 vs. 49 meningeal isolates) and most of them were provided by hospitals involved in the sentinel surveillance project (57 out of 76; 75 %). In this regard, 85.8 % of isolates belonged to seven serotypes that were in order of frequency the following: 14, 19A, 6A, 19F, 6B, 3 and 23F. The serotype coverage of the various multivalent pneumococcal vaccines of possible use was estimated at 54-90 %.
Conclusions: after the introduction of the vaccinations, one might expect that a reduction of the invasive pneumococcal disease occurs due to the serotypes included in the available conjugate vaccines, but emphasis is made on the need of strengthening at present the clinical and epidemiological surveillance system for this disease nationwide.


REFERENCES

  1. WHO. Pneumococcal vaccines WHO position paper-2012-recommendations. Vaccine. 2012;30(32):4717-8.

  2. Center for Disease Control and Prevention. Pneumococcal Disease Epidemiology and prevention of vaccine-preventable diseases.12th edtion. Atlanta: Center for Disease Prevention and Control; 2011. p. 233-48.

  3. Pérez A, Dickinson F, Rodriguez M. Community acquired bacterial meningitis in Cuba: a follow up of a decade. BMC Infectious Diseases. 2010;10:130.

  4. Dickinson F, Rodríguez M, Toraño G. Pneumococcal meningitis in Cuban children and adolescents: A fifteen years follow up. PediatricsResearch International Journal.2015(2015). Article ID 596251.

  5. Toraño G, Llanes R, Pías L, Abreu M, Varcárcel M. Serotipos de Streptococcus pneumoniae en Cuba y progresión de la resistencia a la penicilina. Rev Cubana Med Trop [serie en Internet]. 2010 ago [citado 26 de Mayo de 2016];62(2). Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0375- 07602010000200012&lng=es&nrm=iso&tlng=es

  6. Toraño G, Pías L, Capote M, Rodríguez M, Dickinson F, Varcárcel M. Serotipos y resistencia antimicrobiana de aislamientos meníngeos de Streptococcus pneumoniae. Cuba, 2007-2012. Vacci Monitor. 2014;23(3):117-23.

  7. González N, Paredes B, Pérez S, Mirabal M, Rivero I, González C, et al. Safety and immunogenicity of Cuban antipneumococcal conjugate vaccine PCV7-TT in Healthy Adults. MEDICC Review. 2015;17(4):32-37.

  8. Dotres C, Puga R, Ricardo Y, Broño C, Paredes B, Echemendía V, et al. Safety and preliminary immunogenicity of Cuban pneumococcal conjugate vaccine candidate in healthy children: A randomized phase I clinical trial. Vaccine. 2014;32(41):5266-70.

  9. Perilla MJ, Ajello G, Bopp C, Elliott J, Facklam R, Knapp J, et al. Manual de laboratorio para la identificación y prueba de susceptibilidad a los antimicrobianos de patógenos bacterianos de importancia para la Salud Pública en el mundo en desarrollo. Atlanta: WHO; 2003.

  10. Habib M, Porter BD, Satzke C. Capsular Serotyping of Streptococcus pneumoniae. Using the Quellung Reaction. J Vis Exp. 2014(84):e51208.

  11. Said M, Johnson H, Nonyane B, Deloria-Knoll M, O'Brien KL, Andreo F, et al. Estimating the burden of pneumococcal pneumonia among adults: a systematic review and meta-analysis of diagnostic techniques. PLoS ONE. 2013;8:e60273.

  12. Geno K, Gilbert G, Song J, Skovsted I, Klugman K, Jones C, et al. Pneumococcal capsules and their types: Past, present, and future. Clinical Microbiology Reviews. 2015;28(3):871-99.

  13. Johnson HL, Deloria-Knoll M, Levine OS, Stoszek SK, Freimanis Hance L, et al. Systematic Evaluation of Serotypes Causing Invasive Pneumococcal Disease among Children Under Five: The Pneumococcal Global Serotype Project. PLoS Med. 7(10):e1000348.

  14. Darenberg J, Henriques Normark B. The epidemiology of pneumococcal infectionsthe Swedish experience. Vaccine. 2009;27(supp 6):G27-32.

  15. Van Effelterre T, Moore M, Fierens F, Whitney C, White L, Pelton S, et al. A dynamic model of pneumococcal infection in the United States. Implications for prevention through vaccination. Vaccine. 2010;28:3650-60.

  16. Isaacman D, Mc Intosh D, Reinert R. Burden of invasive pneumococcal disease and serotype distribution among Streptococcus pneumoniae isolates in young children in Europe: impact of the 7-valent pneumococcal conjugate vaccine and considerations for future conjugate vaccines. Inter J Infect Dis. 2010;14:197-209.

  17. Castañeda E, Agudelo CI, Regueira M, Corso A, Brandileone MC, Brandao A, et al. Laboratory-based surveillance of Streptococcus pneumoniae invasive disease in children in 10 Latin American countries. SIREVA II Project, 2000-2005. Pediatric Infec Dis J. 2009;28(9):265-70.

  18. Vakevainen M, Eklund C, Eskola J, Kayhty H. Cross-reactivity of antibodies to type 6B and 6A polysaccharides of Streptococcus pneumoniae, evoked by pneumococcal conjugate vaccines in infants. J Infect Dis. 2001;184(6):789-93.

  19. Kuttel M, Jackson G, Mafata M, Ravenscroft N. Capsular polysaccharide conformations in pneumococcal serotypes 19F and 19A. Carbohydrate Research. 2015;406:27-33.

  20. Hausdorff W, Hoet B, Schuerman L. Do pneumococcal conjugate vaccines provide any cross-protection against serotype 19A? BMC Pediatrics. 2010;10:4.




2020     |     www.medigraphic.com