medigraphic.com
Órgano Oficial de la Asociación Mexicana de Hepatología

2018, Number 1

<< Back Next >>

Ann Hepatol 2018; 17 (1)

Association of Adolescent Obesity with Nonalcoholic Fatty Liver Disease and Related Risk Factors in Xi ’an, China

Rong Y, Chun-Yan N, Hong-Xin Z, Lu Y, Wen W, Yu T

Language: English
References: 21
Page: 85-91
PDF size: 208.05 Kb.


ABSTRACT

Introduction and aim. To investigate the association of adolescent obesity with nonalcoholic fatty liver disease (NAFLD) and related risk factors in Xi 'an, China. Material and methods. A total of 4141 adolescents (2,061 girls and 2,080 boys, mean age: 18.62 ± 0.66 years, age range 15-22 years) were enrolled in this investigation. Anthropometric index was measured, and liver ultrasonography and liver function biochemical test were performed in all the subjects. T test, χ2 test and logistic regression analysis were used for statistical analyses. Results. The total rates of obesity was 7.9% (08/4,141). The prevalence rate of NAFLD was 8.1% (335/4141) with a declining trend from obesity, overweight to normal BMI. NAFLD prevalence rate in obese boys was significantly higher than in girls (χ2 = 56.5, P ‹ 0.01). BMI, body weight, ALT, and AST in NAFLD group were higher than in non-NAFLD group (P ‹ 0.05). The tangent point of ALT was 36 U/L using Youden index in boys, and 33 U/L in girls. Conclusion. The prevalence of obesity and NAFLD in adolescents is higher in Xi'an than anticipated. Body weight and BMI may be the associated independent risk factors of NAFLD.


REFERENCES

  1. Day CP. Non-alcoholic fatty liver disease: a massive problem. Clin Med 2011; 11: 176-8.

  2. Mencin AA, Lavine JE. Nonalcoholic fatty liver disease in children. Curr Opin Clin Nutr Metab Care 2011; 14: 151-7.

  3. Valentina G, Federica P, Francesca G, Valerio N. Pediatric non alcoholic fatty liver disease: old and new concepts on development, progression, metabolic insight and potential treatment targets. BMC Pediatrics 2013; 13: 40-3.

  4. Zhang XM, Wan YP, Xu RY, Chen ZQ, Liu H, Xu M, Fang H. The comparative analysis of high school students’ obesity and nonalcoholic fatty liver disease in Shanghai at different times. J Clin Pediatr 2010; 28: 823-6.

  5. Chang M, Xiao YF, Yin CY, Yi XQ, Xu ED. Epidemiological investigation of overweight and obese children and adolescents aged 7-18 in Xi'an city in 2009. Chin J Child Care 2012; 20: 224-7.

  6. WGOC. The weight index classification standards of Chinese school-age children and adolescents overweight and obesity. Chin J Epidemiol 2004; 2: 97-102.

  7. CMA.Ultrasonic medical fascicle of clinical technical operation standard. People's Military Doctor Press 2007; 79.

  8. The branch of the CMA endocrinology obesity group. China adult obesity prevention expert consensus. Chin J Endocrinol Metab 2011; 27: 711-17.

  9. Frank BH. The trend of obesity and the risk of developing type 2 diabetes and the impact of policy. Chin J Int Med 2014; 53: 124-7.

  10. Donna Spruijt-Metz. Etiology, Treatment and Prevention of Obesity in Childhood and Adolescence: A Decade in Review. J Res Adolesc 2011; 21: 129-52.

  11. Chaput JP, Després JP, Bouchard C, Tremblay A. The association between sleeps duration and weight gain in adults: a 6-year prospective study from the Quebec Family Study. Sleep 2008; 31: 517-23.

  12. Lawlor DA, Callaway M, Macdonald-Wallis C, Anderson E, Fraser A, Howe LD, Day C, et al. Nonalcoholic Fatty Liver Disease, Liver Fibrosis, and Cardiometabolic Risk Factors in Adolescence: A Cross-Sectional Study of 1874 General Population Adolescents. J Clin Endocrinol Metab 2014; 1: 36-42.

  13. Kang RT, Zhong Y, Jiang YH, Liu KX, You C, Kang RT, Zhong Y, et al. Influence factors analysis of nonalcoholic fatty liver disease in Obese children. Practical Preventive Medicine 2013; 20: 277-9.

  14. Younossi ZM, Stepanova M, Afendy M, Fang Y, Younossi Y, Mir H, Srishord M. Changes in the prevalence of the most common causes of chronic liver diseases in the United States from 1988 to 2008. Clin Gastroenterol Hepatol 2011; 9: 524-30.

  15. Long DB, Li XL. Ultrasonic diagnosis of children and adolescents fatty liver and correlation with obesity. Modern Medicine & Health 2012; 28: 2432-3.

  16. Florentino G, Cotrim HP, Florentino A. Hormone replacement therapy in menopausal women: risk factor or protection to nonalcoholic fatty liver disease. Ann Hepat 2012; 11: 147-9.

  17. Kovanlikaya A, Mittelman SD, Ward A, Geffner ME, Dorey F, Gilsanz V. Obesity and fat quantifi cation in lean tissues using three-point Dixon MR imaging. Pediatr Radio 2005; 35: 601-7.

  18. Hagström H, Stĺl P, Hultcrantz R, Hemmingsson T, Andreasson A. Overweight in late adolescence predicts development of severe liver disease later in life: A 39 years follow-up study. J Hepatology 2016; 65: 363-8.

  19. Liver Fatty Liver and Alcoholic Liver Disease Group of CMA. Onalcoholic fatty liver disease diagnosis and treatment guidelines. Chin J Hepatic 2010; 18: 163-5.

  20. Prati D, Taioli E, Zanella A, Della Torre E, Butelli S, Del Vecchio E, Vianello L, et al. Updated definitions of healthy ranges for serum alanine aminotransferase levels. Ann Intern Med 2002; 137: 1-10.

  21. Siddiqui MS, Sterling RK, Luketic VA, Puri P, Stravitz RT, Bouneva I, Boyett S, et al. Association Between High-Normal Levels of Alanine Aminotransferase and Risk Factors for Atherogenesis. Gastroenterology 2013; 145: 1271-9.




2020     |     www.medigraphic.com