2018, Number 1
Hepatic Hydrothorax
Language: English
References: 131
Page: 33-46
PDF size: 205.52 Kb.
ABSTRACT
Hepatic hydrothorax (HH) is a pleural effusion that develops in a patient with cirrhosis and portal hypertension in the absence of cardiopulmonary disease. Although the development of HH remains incompletely understood, the most acceptable explanation is that the pleural effusion is a result of a direct passage of ascitic fluid into the pleural cavity through a defect in the diaphragm due to the raised abdominal pressure and the negative pressure within the pleural space. Patients with HH can be asymptomatic or present with pulmonary symptoms such as shortness of breath, cough, hypoxemia, or respiratory failure associated with large pleural effusions. The diagnosis is established clinically by finding a serous transudate after exclusion of cardiopulmonary disease and is confirmed by radionuclide imaging demonstrating communication between the peritoneal and pleural spaces when necessary. Spontaneous bacterial empyema is serious complication of HH, which manifest by increased pleural fluid neutrophils or a positive bacterial culture and will require antibiotic therapy. The mainstay of therapy of HH is sodium restriction and administration of diuretics. When medical therapy fails, the only definitive treatment is liver transplantation. Therapeutic thoracentesis, indwelling tunneled pleural catheters, transjugular intrahepatic portosystemic shunt and thoracoscopic repair of diaphragmatic defects with pleural sclerosis can provide symptomatic relief, but the morbidity and mortality is high in these extremely ill patients.REFERENCES
104.Riggio O, Angeloni S, Salvatori FM, De Santis A, Cerini F, Farcomeni A, Attili AF, et al. Incidence, natural history, and risk factorsof hepatic encephalopathy after transjugular intrahepatic portosystemic shunt with polytetrafluoroethylene- covered stent grafts. Am J Gastroenterol 2008; 103: 2738-46.
131.Park SZ, Shrager JB, Allen MS, Nagorney DM. Treatment of refractory, nonmalignant hydrothorax with a pleurovenous shunt. Ann Thorac Surg 1997; 63: 1777-9. 132.Artemiou O, Marta GM, Klepetko W, Wolner E, Muller MR. Pleurovenous shunting in the treatment of nonmalignant pleural effusion. Ann Thorac Surg 2003; 76: 231-3. 133.Hadsaitong D, Suttithawil W. Pleurovenous shunt in treating refractory nonmalignant hepatic hydrothorax: a case report. Respir Med 2005; 99: 1603-05. 134.Perera E, Bhatt S, Dogra VS. Complications of Denver shunt. J Clin Imaging Sci 2011; 1: 6. 135.Krowka MJ, Wiesner RH, Heimbach JK. Pulmonary contraindications, indications and MELD exceptions for liver transplantation: a contemporary view and look forward. J Hepatol 2013; 59: 367-74. 136.Xiol X, Tremosa G, Castellote J, Gornals J, Lama C, Lopez C, Figueras J. Liver transplantation in patients with hepatic hydrothorax. Transpl Int 2005; 18: 672-5. 137.Serste T, Moreno C, Francoz C, Razek WA, Paugham C, Belghitti J, Valla D, et al. The impact of preoperative hepatic hydrothorax on the outcome of adult liver transplantation. Eur J Gastroenterol Hepatol 2010; 22: 207-12. 138.Endo K, Iida T, Yagi S, Yoshizawa A, Fujimoto Y, Ogawa K, Ogura Y, et al. Impact of preoperative uncontrollable hepatic hydrothorax and massive ascites in adult liver transplantation. Surg Today 2014; 44: 2293-9. 139.Bozbas SS, Eyuboglu F. Evaluation of liver transplant candidates: A pulmonary perspective. Ann Thorac Med 2011; 6: 109-14.