Mesa GL, Castañeda TM, Montero LM, Mojena LX, Ricardo RN, Jiménez SM

Language: Spanish
References: 0
Page: 39-49
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ABSTRACT

Introduction: Platelet aggregation studies allow the identification of patients with functional disorders and the monitoring of antiplatelet therapies, establishing classic patterns. Because there is no agreement on the establishment of reference ranges, numerous efforts are currently being made to improve the standardization of this test.
Objectives: To establish reference values for platelet aggregation studies with different agonists by comparing them with those preset in the literature, at Hermanos Ameijeiras Hospital. To identify the influence of the variables sex, smoking habits and alcohol consumption.
Methods: An observational, descriptive, cross-sectional study of platelet aggregation using different agonists was performed in the clinical laboratory of Hermanos Ameijeiras Hospital, between September 2009 and September 2015. The study population consisted of 192 donors from the blood bank, used as control group. The reference ranges of platelet aggregation with the different agonists were obtained using the 2.5 (P2.5) and 97.5 (P97.5) percentiles. In order to compare this study's population mean with the sample mean preset in the literature, we used the T-test for one sample.
Results: The mean of aggregation percentage obtained in our study with each agonist was ADP (62.4 %), epinephrine (66.4 %), collagen (69.9 %), and ristocetin (69.7 %). The reference ranges in the research with each agonist were the following: ADP (44.1-86.7 %), epinephrine (50.8-80.0 %), collagen (60.0-85.5 %), and ristocetin (52.9-91.7 %).
Conclusions: The variables gender, smoking and alcohol consumption did not influence the results of the platelet aggregation study. The results of the population for the platelet aggregation study presented statistically significant differences when compared with the values of aggregation preset in the literature.