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2017, Number 6

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Ann Hepatol 2017; 16 (6)

The Great Chinese Famine Exposure in Early Life and the Risk of Nonalcoholic Fatty Liver Disease in Adult Women

Zheng X, Ren W, Gong L, Long J, Luo R, Wang Y

Language: English
References: 35
Page: 901-908
PDF size: 153.66 Kb.


ABSTRACT

Introduction and aim. Previous studies found famine exposure was associated with a higher risk of metabolic syndrome (MetS). In the study, we investigated the relationship between Chinese famine exposure and the risk of nonalcoholic fatty liver disease (NAFLD) in adult women. Materials and methods. Data were obtained from subjects via routine physical examinations in the Public Health Center of our hospital between 2011 and 2014. Women were categorized into the following three groups: control, prenatally exposed, and postnatally exposed. Hepatic steatosis was diagnosed according to the guidelines established for the diagnosis and treatment of NAFLD. Results. The prevalence rates of NAFLD among non-exposed, prenatally, and postnatally exposed women were 17.3, 23.0, and 22.9%, respectively. Pre-exposed and postnatally exposed women had higher risks of NAFLD, exhibiting ORs (95% CI) of 1.33 (1.04-1.70) and 1.26 (1.03-1.55), respectively. Prenatally, but not postnatally, exposed women had significantly higher risks of having abnormal alanine aminotransferase (ALT), with ORs of 1.30 (1.05-1.61). Conclusions. The results indicate a significant association between famine exposure in early life and the risk of NAFLD in adult women. Prenatally exposed women displayed higher risks of NAFLD and mild, moderate and severe steatosis.


REFERENCES

  1. Huang C, Li Z, Wang M, Martorell R. Early life exposure to the 1959-1961 Chinese famine has long-term health consequences. J Nutr 2010; 10: 1874-8.

  2. Lussana F, Painter RC, Ocke MC, Buller HR, Bossuyt PM, Roseboom TJ. Prenatal exposure to the Dutch famine is associated with a preference for fatty food and a more atherogenic lipid profile. Am J Clin Nutr 2008; 88: 1648-52.

  3. Li Y, He Y, Qi L, Jaddoe VW, Feskens EJ, Yang X, Ma G, et al. Exposure to the Chinese famine in early life and the risk of hyperglycemia and type 2 diabetes in adulthood. Diabetes 2010; 59: 2400-6.

  4. Li Y, Jaddoe VW, Qi L, He Y, Wang D, Lai J, Zhang J, et al. Exposure to the Chinese famine in early life and the risk of metabolic syndrome in adulthood. Diabetes Care 2011; 34(4): 1014-8.

  5. Zheng X, Wang Y, Ren W, Luo R, Zhang S, Zhang JH, Zeng Q. Risk of metabolic syndrome in adults exposed to the great Chinese famine during the fetal life and early childhood. Eur J Clin Nutr 2012; 66(2): 231-6.

  6. Fan JG, Farrell GC. Epidemiology of non-alcoholic fatty liver disease in China. J Hepatol 2009; 50(1): 204-10.

  7. Masarone M, Federico A, Abenavoli L, Loguercio C, Persico M. Non alcoholic fatty liver: epidemiology and natural history. Rev Recent Clin Trials 2014; 9(3): 126-33.

  8. Li H, Wang YJ, Tan K, Zeng L, Liu L, Liu FJ, Zhou TY, et al. Prevalence and risk factors of fatty liver disease in Chengdu, Southwest China. Hepatobiliary Pancreat Dis Int 2009; 8(4): 377-82.

  9. Fotbolcu H, Zorlu E. Nonalcoholic fatty liver disease as a multi-systemic disease. World J Gastroenterol 2016; 22: 4079-90.

  10. Abenavoli L, Milic N, Di Renzo L, Preveden T, Medic-Stojanoska M, De Lorenzo A. Metabolic aspects of adult patients with nonalcoholic fatty liver disease. World J Gastroenterol 2016; 22(31): 7006-16.

  11. van Abeelen AF, Elias SG, Bossuyt PM, Grobbee DE, van der Schouw YT, Roseboom TJ, Uiterwaal CS. Famine exposure in the young and the risk of type 2 diabetes in adulthood. Diabetes 2012; 61(9): 2255-60.

  12. Wang Y, Wang X, Kong Y, Zhang JH, Zeng Q. The great Chinese famine leads to shorter and overweight females in Chongqing Chinese population after 50 years. Obesity (Silver Spring) 2010; 18: 588-92.

  13. Barker DJ, Bull AR, Osmond C, Simmonds SJ. Fetal and placental size and risk of hypertension in adult life. BMJ 1990; 301: 259-62.

  14. Barker DJ, Gluckman PD, Godfrey KM, Harding JE, Owens JA, Robinson JS. Fetal nutrition and cardiovascular disease in adult life. Lancet 1993; 341: 938-41.

  15. Bispham J, Gardner DS, Gnanalingham MG, Stephenson T, Symonds ME, Budge H. Maternal nutritional programming of fetal adipose tissue development: differential effects on messenger ribonucleic acid abundance for uncoupling proteins and peroxisome proliferator-activated and prolactin receptors. Endocrinology 2005; 146: 3943-9.

  16. Chen Y, Zhou LA. The long-term health and economic consequences of the 1959-1961 famine in China. J Health Econ 2007; 26(4): 659-81. 17 Cai Y, Wang F. Famine, social disruption, and involuntary fetal loss: evidence from Chinese survey data. Demography 2005; 42(2): 301-22.

  17. Zeng MD, Fan JG, Lu LG, Li YM, Chen CW, Wang BY, Mao YM, et al. Guidelines for the diagnosis and treatment of nonalcoholic fatty liver diseases. J Dig Dis 2008; 9: 108-112.

  18. Brumbaugh DE, Friedman JE. Developmental origins of nonalcoholic fatty liver disease. Pediatr Res 2014;75(1-2): 140-7.

  19. Bruce KD, Cagampang FR, Argenton M, Zhang J, Ethirajan PL, Burdge GC, Bateman AC, et al. Maternal high-fat feeding primes steatohepatitis in adult mice offspring, involving mitochondrial dysfunction and altered lipogenesis gene expression. Hepatology 2009; 50(6): 1796-808.

  20. Charlton M. Fetal obesity syndrome: maternal nutrition as a cause of nonalcoholic steatohepatitis. Hepatology 2009; 50(6): 1696-8.

  21. King JC. Maternal obesity, metabolism, and pregnancy outcomes. Annu Rev Nutr 2006; 26: 271-91.

  22. Jones HN, Woollett LA, Barbour N, Prasad PD, Powell TL, Jansson T. High-fat diet before and during pregnancy causes marked up-regulation of placental nutrient transport and fetal overgrowth in C57/BL6 mice. FASEB J 2009; 23: 271-8.

  23. Samuelsson AM, Matthews PA, Argenton M, Christie MR, McConnell JM, Jansen EH, Piersma AH, et al. Diet-induced obesity in female mice leads to offspring hyperphagia, adiposity, hypertension, and insulin resistance: a novel murine model of developmental programming. Hypertension 2008; 51: 383-92.

  24. Srinivasan M, Katewa SD, Palaniyappan A, Pandya JD, Patel MS. Maternal high-fat diet consumption results in fetal malprogramming predisposing to the onset of metabolic syndrome-like phenotype in adulthood. Am J Physiol Endocrinol Metab 2006; 291: E792-9.

  25. Bruce KD, Byrne CD.The metabolic syndrome: common origins of a multifactorial disorder. Postgrad Med J 2009; 85(1009): 614-21.

  26. Bril F, Maximos M, Portillo-Sanchez P, Biernacki D, Lomonaco R, Subbarayan S, Correa M, et al. Relationship of vitamin D with insulin resistance and disease severity in non-alcoholic steatohepatitis. J Hepatol 2015; 62(2): 405-11.

  27. Nascimento FA, Ceciliano TC, Aguila MB, Mandarim-de-Lacerda CA. Transgenerational effects on the liver and pancreas resulting from maternal vitamin D restriction in mice. J Nutr Sci Vitaminol (Tokyo) 2013; 59(5): 367-74.

  28. Boujendar S, Reusens B, Merezak S, Ahn MT, Arany E, Hill D, Remacle C. Taurine supplementation to a low protein diet during foetal and early postnatal life restores a normal proliferation and apoptosis of rat pancreatic islets. Diabetologia 2002; 45: 856-66.

  29. Alimujiang A, Mo M, Liu Y, Huang NS, Liu G, Xu W, Wu J, et al. The association between China’s Great famine and risk of breast cancer according to hormone receptor status: a hospital-based study. Breast Cancer Res Treat 2016; 160(2): 361-9.

  30. Clark JM, Brancati FL, Diehl AM. The prevalence and etiology of elevated aminotransferase levels in the United States. Am J Gastroenterol 2003; 98: 960-7.

  31. Schwimmer JB, Deutsch R, Rauch JB, Behling C, Newbury R, Lavine JE. Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr 2003; 143: 500-5.

  32. Sathya P, Martin S, Alvarez F. Nonalcoholic fatty liver disease (NAFLD) in children. Curr Opin Pediatr 2002; 14: 593-600.

  33. Huang C, Li Z, Wang M, Martorell R. Early life exposure to the 1959-1961 Chinese famine has long-term health consequences. J Nutr 2010; 140(10): 1874-8.

  34. Wang PX, Wang JJ, Lei YX, Xiao L, Luo ZC. Impact of fetal and infant exposure to the Chinese Great Famine on the risk of hypertension in adulthood. PLoS One 2012; 7(11): e49720.

  35. Xu J, He G, Zhu J, Zhou X, St Clair D, Wang T, Xiang Y, et al. Prenatal nutritional deficiency reprogrammed postnatal gene expression in mammal brains: implications for schizophrenia. Int J Neuropsychopharmacol 2014; 18(4): 10.




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