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2017, Number 4

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Rev Mex Patol Clin Med Lab 2017; 64 (4)

Effect of age and intensity of donations on serum immunoglobulin concentration in voluntary plasma donors

Benítez ZMB, Sánchez FP, Alonso RA, Hernández SM, Fernández FI, Collazo DM

Language: Spanish
References: 17
Page: 158-162
PDF size: 300.24 Kb.


ABSTRACT

Introduction: Several researchers have shown that the intensity of plasma donation do not affect the immunoglobulins concentration. However, the authors of this research have seen fluctuations in the IgM concentration with a tendency to decrease in plasma donors. Goals: To describe the behavior of the IgG & IgM concentration and their relationship with sociodemographic characteristic in donors. Material and methods: Cross sectional study was conducted in the Provincial Blood Bank of Cienfuegos, from August 2013 to May 2016. By simple random selection, the sample was formed by 50 donors. The sociodemographic characteristic, sex, age and intensity of the donations are collected by a documentary review in the clinical records. In addition, the result of the immunoglobulin assays performed in the baseline and the periodic form in the selected individuals. The descriptive statistics, mean, minimum and maximum value, standard deviation for all measurements were calculated. To determine the differences between the group means, a hypothesis test was carried out using the nonparametric method. Results: There were no differences between the initial measurement and the serial ones in the donations for IgG. However, in the case of IgM, there is a significant statistical reduction in these values, more notable in the donors with higher ages and who present lower values in the baseline measurement. The intensity of donations did not influence serum IgM levels. Conclusions: According to the evidence found, it seems that regular plasma donation can influence the concentration of IgM.


REFERENCES

  1. Procedimiento normalizado de operación. PNO: D-PF-01. Captación, selección y preparación de donantes para aféresis productiva. Rev.02.2014. Banco de Sangre Provincial de Cienfuegos.

  2. Centro para el Control Estatal de la Calidad de los Medicamentos. Regulación No. 9-2006. Obtención de plasma humano mediante plasmaféresis productiva automatizada. La Habana: CECMED; 2006.

  3. Palmer DS, Scalia V, O’Toole J, Welch C, Yi Q, Goldman M. Incidence of gammopathies in long-term plasmapheresis donors at Canadian Blood Services. Transfusion. 2015; 55 (6): 1347-1354.

  4. Wasi S, Santowski T, Murray SA, Perrault RA, Gill P. The Canadian Red Cross plasmapheresis donor safety program: changes in plasma proteins after long-term plasmapheresis. Vox Sang. 1991; 60 (2): 82-87.

  5. Tran-Mi B, Storch H, Seidel K, Schulzki T, Haubelt H, Anders C et al. The impact of different intensities of regular donor plasmapheresis on humoral and cellular immunity, red cell and iron metabolism, and cardiovascular risk markers. Vox Sang. 2004; 86 (3): 189-197.

  6. Pérez-Trufín A, Marcel-Ranzola R, Villar-Valdés M, Fernández-Jure I, Madrazo-Gutiérrez Y, Mirabal-Pozo I. Comportamiento de las concentraciones de proteínas plasmáticas en donantes de plasma. Medicentro [Internet]. 2009 [citado 16 agosto 2014]; 13 (1): [aprox. 12 p.]. Disponible e: http://www.medicentro.sld.cu/index.php/medicentro/article/view/326

  7. Bechtloff S, Tran-My B, Haubelt H, Stelzer G, Anders C, Hellstern P. A prospective trial on the safety of long-term intensive plasmapheresis in donors. Vox Sang. 2005; 88 (3): 189-195.

  8. Schulzki T, Seidel K, Storch H, Karges H, Kiessig S, Schneider S et al. A prospective multicentre study on the safety of long-term intensive plasmapheresis in donors (SIPLA). Vox Sang. 2006; 91 (2): 162-173.

  9. Friedman BA, Schork MA, Mocniak JL, Oberman HA. Short-term and long-term effects of plasmapheresis on serum proteins and immunoglobulins. Transfusion. 1975; 15 (5): 467-472.

  10. Hortin GL. Amino acids, peptides, and proteins. In: Burtis CA, Ashwood ER, Bruns DE. Tietz textbook of clinical chemistry and molecular diagnostics. 5 ed. Missouri, Estados Unidos: Elsevier Saunders; 2012. p. 544-546.

  11. Receptor de los linfocitos B, los anticuerpos y sus funciones. En: Pérez-Martin O, Vega-García I. Inmunología en el humano sano. La Habana: Editorial Ciencias Médicas; 2017. p. 23-27. Disponible en: http://bvs.sld.cu/libros/inmunologia_humano_sano/epub_inmunologia_sano.htm

  12. Taylor JJ, Pape KA, Jenkins MK. A germinal center-independent pathway generates unswitched memory B cells early in the primary response. J Exp Med. 2012; 209 (3): 597-606.

  13. Chen X, Li G, Wan Z, Liu C, Zeng Y, Liu W. How B cells remember? A sophisticated cytoplasmic tail of mIgG is pivotal for the enhanced transmembrane signaling of IgG-switched memory B cells. Prog Biophys Mol Biol. 2015; 118 (3): 89-94.

  14. Saavedra-Hernández D, García-Verdecia B. Inmunosenescencia: efectos de la edad sobre el sistema inmune. Rev Cubana Hematol Inmunol Hemoter. 2014; 30 (4): 332-345.

  15. Características distintivas de la respuesta inmune en el curso de la vida. En: Pérez-Martin O, Vega-García I. Inmunología en el humano sano. La Habana: Editorial Ciencias Médicas; 2017. p. 97-100. Disponible en: http://bvs.sld.cu/libros/inmunologia_humano_sano/epub_inmunologia_sano.htm

  16. Colonna-Romano G, Bulati M, Aquino A, Pellicanò M, Vitello S, Lio D et al. A double-negative (IgD-CD27-) B cell population is increased in the peripheral blood of elderly people. Mech Ageing Dev. 2009; 130 (10): 681-690.

  17. Biblioteca de Pruebas. Servicio de Inmunología. AGC – Laboratorio de Medicina. 10 de diciembre de 2012. Disponible en: http://www.hca.es/huca/web/contenidos/websdepartam/Cartera%20Laboratorios/Inmunologia.pdf




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