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ISSN 1028-4818 (Electronic)

2017, Number 6

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Mul Med 2017; 21 (6)

Common variable immunodeficiency. The first case in Granma province

Marrón GR, Addine RBC

Language: Spanish
References: 21
Page: 949-959
PDF size: 156.72 Kb.


ABSTRACT

Common variable immunodeficiency is considered the phenotypic expression of a set of genetic defects of the immune system with complex hereditary patterns. Its manifestations are related to the loss or diminution in the functions of the B lymphocytes. It is a primary immunodeficiency, can debut in adulthood and concomitant with allergic diseases, autoimmune or some neoplastic diseases and in particular there can exist personal and familiar pathological antecedents of deficit of IgA. Its main clinical manifestations are associated with frequent infectious diseases, with a poor evolution and low serum levels of all immunoglobulin isotypes. The case of a patient with this disease, who comes to the consultation referred by the service of rheumatology with presence of articular pains and decay, is consulted. With the use of the clinical method and the immunological studies that showed the presence of values in 0 in two immunoglobulin isotypes and very low in one case, the disease was diagnosed and other studies were carried out.


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