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2018, Number 1

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Rev Med Inst Mex Seguro Soc 2018; 56 (1)

Obesity hypoventilation syndrome and pulmonary hypertension. An association littleknown in Mexico

Díaz-Domínguez E, Rosas-Peralta M, Santos-Martínez LE, Rodríguez-Almendros NA, Magaña-Serrano JA, Pérez-Rodríguez G

Language: Spanish
References: 49
Page: 72-83
PDF size: 374.26 Kb.


ABSTRACT

The obesity hypoventilation syndrome (OHS) refers to the combination of obesity, daytime hypercapnia and sleep-disordered breathing. Obesity has risen to epidemic proportions in the last three decades in the United States, Mexico and Europe. The OHS is associated with obstructive sleep apnea syndrome in 30%. Without treatment, mortality is 46% at 50 months. So in this paper we analyze the OHS, obesity and pulmonary hypertension, the pathophysiology, clinical presentation and diagnosis as well as the treatment, which is aimed at the correction of sleep-disordered breathing and hypoxemia; although there is little experience with the use of specific pulmonary vasodilator drugs.


REFERENCES

  1. Mokhlesi B. Obesity hypoventilation syndrome: A state-of-the-art review. Respir Care. 2010 Oct;55 (10):1347-62; discussion 1363-5.

  2. Organisation for Economic Co-operation and Development (OECD) Directorate for Employment, Labour and Social Affairs. Obesity update. June 2014.

  3. Prentice A, Webb F. Obesity amidst poverty. Int J Epidemiol. 2006;35(1):24-30.

  4. McTigue K, Larson JC, Valoski A, Burke G, Kotchen J, Lewis CE, et al. Mortality and cardiac and vascular outcomes in extremely obese women. JAMA. 2006;296(1):79-86.

  5. Freedman DS, Khan LK, Serdula MK, Galuska DA, Dietz WH. Trends and correlates of class 3 obesity in the United States from 1990 through 2000. JAMA. 2002;288(14):1758-61.

  6. Sturm R. Increases in clinically severe obesity in the United States, 1986-2000. Arch Intern Med. 2003; 163(189):2146-8.

  7. McPherson K, Marsh T, Brown M. Foresight. Tackling obesities: Future choices -modelling future trends in obesity and their impact on health. London: Government Office for Sciences; 2007. Disponible en www. foresight.gov.uk/Obesity/14.pdf

  8. Macavei VM, Spurling KJ, Loft J, Makker HK. Diagnostic predictors of obesity-hypoventilation syndrome in patients suspected of having sleep dis ordered breathing. J Clin Sleep Med. 2013;9(9): 879-84.

  9. Organización para la Cooperación y el Desarrollo Económicos. La obesidad y la economía de la prevención: “Fit not fat”. Hechos claves-México. Actualización 2014. Disponible en www.oecd.org/health/health-systems/ Obesity-Update-2014-MEXICO_ES.pdf

  10. Olson AL, Zwillich C. The obesity hypoventilation syndrome. Am J Med. 2005; 118(9):948-56.

  11. Mokhlesi B, Tulaimat A, Faibussowitsch I, Wang Y, Evans AT. Obesity hypoventilation syndrome: prevalence and predictors in patients with obstructive sleep apnea. Sleep Breath. 2007;11(2):117-24.

  12. Kessler R, Chaouat A, Schinkewitch P, Faller M, Casel S, Krieger J, et al. The obesity-hypoventilation syndrome revisited. A prospective study of 34 consecutive cases. Chest. 2001;120(2):369-76.

  13. Piper AJ, Grunstein RR. Obesity hypoventilation syndrome. Mechanisms and management. Am J Respir Crit Care Med. 2011;183(3):292-8.

  14. Cabrera-Lacalzada C, Díaz-Lobato S. Grading obesity hypoventilation syndrome severity. Eur Respir J. 2008;32(3):817-8.

  15. Balachandran JS, Masa JF, Mokhlesi B. Obesity hypoventilation syndrome epidemiology and diagnosis. Sleep Med Clin. 2014;9(3):341-7.

  16. Bednarek M. The overlap syndrome of chronic obstructive pulmonary disease and obstructive sleep apnoea. Pneumol Alergol Pol. 2011;79:67-9.

  17. Bednarek M, Plywaczewski R, Jonczak L, Zielinski J, et al. There is no relationship between chronic obstructive pulmonary disease and obstructive sleep apnea syndrome: a population study. Respiration. 2005;72(2):142-9.

  18. Blüher A. Are there still healthy obese patients? Curr Opin Endocrinol Diabetes Obes. 2012;19(5):341-6.

  19. Verbraecken J, McNicholas WT. Respiratory mechanics and ventilatory control in overlap syndrome and obesity hypoventilation. Respir Res. 2013;14:132.

  20. Becker HF, Piper AJ, Flynn WE, McNamara SG, Grunstein RR, Peter JH, et al. Breathing during sleep in patients with nocturnal desaturation. Am J Respir Crit Care Med. 1999;159(1):112-8.

  21. Haque AK, Gadre S, Taylor J, Haque SA, Freeman D, Duarte A. Pulmonary and cardiovascular complications of obesity. An autopsy study of 76 obese subjects. Arch Pathol Lab Med. 2008;132(9):1397-404.

  22. Howard LS, Graspa J, Dawson D, Bellamy M, Chambers JB, Masani ND, et al. Echocardiographic assessment of pulmonary hypertension: standard operating procedure. Eur Respir Rev. 2012;21(125): 239-48.

  23. Kauppert CA, Dvorak I, Kollert F, Heinemann F, Jörres RA, Pfeifer M, et al. Pulmonary hypertension in obesity-hypoventilation syndrome. Respir Med. 2013;107(12):2061-70.

  24. Valencia-Flores M, Rebollar V, Santiago V, Orea A, Rodríguez C, Resendiz M, et al. Prevalence of pulmonary hypertension and its association with respiratory disturbances in obese patients living at moderately high altitude. Int J Obes Relat Metab Disord. 2004;28(9):1174-80.

  25. Summer R, Walsh K, Medoff BD. Obesity and pulmonary arterial hypertension: Is adiponectin the molecular link between these conditions? Pulm Circ. 2011;1(4):440-7.

  26. Chaouat A, Weitzenblum E, Krieger J, Oswald M, Kessler R. Pulmonary hemodynamics in the obstructive sleep apnea syndrome. Results in 220 consecutive patients. Chest. 1996 Feb;109(2):380-6.

  27. Barros A, Baptista R, Nogueira A, Jorge E, Teixeira R, Castro G, et al. Predictors of pulmonary hypertension after intermediate-to-high risk pulmonary embolism. Rev Port Cardiol. 2013;32(11):857-64.

  28. Zkarikov S, Swenson ER, Lanaspa M, Block ER, Patel JM, Johnson RJ. et al. Could uric acid be a modifiable risk factor in subjects with pulmonary hypertension? Med Hypotheses. 2010;74(6):1069-74.

  29. Hoeper MM, Bogaard HJ, Condliffe R, Frantz R, Khanna D, Kurzyna M, et al. Definitions and diagnosis of pulmonary hypertension. J Am Coll Cardiol. 2013;62(25 Suppl):D42-D50.

  30. Lopez PP, Stefan B, Schulman CI, Byers PM. Prevalence of sleep apnea in morbidly obese patients who presented for weight loss surgery evaluation: more evidence for routine screening for obstructive sleep apnea before weight loss surgery. Am Surg. 2008; 74(9):834-8.

  31. Malbois M, Giusti V, Suter M, Pellaton C, Vodoz JF, Heinzer R. Oximetry alone versus portable polygraphy for sleep apnea screening before bariatric surgery. Obes Surg. 2010;20(3):326-31.

  32. Fujiki M, Guta CG, Lemmens HJ, Brock-Utne JG. Is it more difficult to cannulate the right internal jugular vein in morbidly obese patients than in non-obese patients? Obes Surg. 2008;18(9):1157-9.

  33. Chanda A, Kwon J, Wolff AJ, Manthous CA. Positive pressure for obesity hypoventilation syndrome. Pulm Med. 2012; 568690. doi:10.1155/2012/568690.

  34. Banerjee D, Yee BJ, Piper AJ, Zwillich CW, Grunstein RR. Obesity hypoventilation syndrome. Hypoxemia during continuous positive airway pressure. Chest. 2007;131(6):1678-84.

  35. Contal O, Adler D, Borel JC, Espa F, Perrig S, Rodenstein D, et al. Impact of different backup respiratory rates on the efficacy of noninvasive positive pressure ventilation in obesity hypoventilation syndrome. Chest. 2013;143(1):37-46.

  36. Piper AJ, Wang D, Yee BJ, Barnes DJ, Grunstein RR. Randomised trials of CPAP vs bilevel support in the treatment of obesity hypoventilation syndrome without severe nocturnal desaturation. Thorax. 2008;63(5):395-401.

  37. Shujaat A, Bellardini J, Girdhar A, Bajwa AA. Use of pulmonary arterial hypertension-specific therapy in overweight or obese patients with obstructive sleep apnea and pulmonary hypertension. Pulm Circ. 2014;4(2):244-9.

  38. Hardinge M, Annandale J, Bourne S, Cooper B, Evans A, Freeman D, et al. British Thoracic Society guidelines for home oxygen use in adults. Thorax. 2015;70 Suppl 1:i1-i43.

  39. Wijesinghe M, Williams M, Perin K, Weatherall M, Beasley R. The effect of supplemental oxygen on hypercapnia in subjects with obesity-associated hypoventilation. Chest. 2011;139(5):1018-24.

  40. Hollier CA, Harmer AR, Maxwell LJ, Menadue C, Willson GN, Unger G, et al. Moderate concentrations of supplemental oxygen worsen hipercapnia in obesity hypoventilation syndrome: a randomised crossover study. Thorax. 2014;69(4):346-53.

  41. Berry RB, Chediak A, Brown LK, Finder J, Gozal D, Iber C, et al. Best clinical practices for the sleep center adjustment of noninvasive positive pressure ventilation (NPPV) in stable chronic alveolar hypoventilation syndromes. J Clin Sleep Med. 2010;6 (5):491-509.

  42. Priou P, Hamel JF, Person C, Meslier N, Racineux JL, Urban T, et al. Long-term outcome of noninvasive positive pressure ventilation for obesity hypoventilation syndrome. Chest. 2010;138(1):84-90.

  43. Castro-Añon O, Pérez de Llano LA, De la Fuente Sánchez S, Golpe R, Méndez Marote L, Castro- Castro J, et al. Obesity-hypoventilation syndrome: increased risk of death over sleep apnea syndrome. PLos One 2015;10(2):e0117808. doi: 10.1371/journal. pone.0117808.

  44. Assi TB, Baz E. Current applications of therapeutic phlebotomy. Blood Transfus. 2014;12 Suppl 1:S75-83.

  45. Fernández AZ, Demaria EJ, Tichansky DS, Kellum JM, Wolfe LG, Meador J, et al. Multivariate analysis of risk factors for death following gastric bypass for treatment of morbid obesity. Ann Surg. 2004;239(5):698-703.

  46. Dixon JB, Schachter LM, O’Brien PE, Dixon JB, Schachter LM, O’Brien PE, et al. Surgical vs conventional therapy for weight loss treatment of obstructive sleep apnea. A randomized controlled trial. JAMA. 2012;308(11):1142-9.

  47. Kim SH, Eisele DW, Smith PL, Schneider H, Schwartz AR. Evaluation of patients with sleep apnea after tracheotomy.Arch Otolaryngol Head Neck Surg. 1998 Sep;124(9):996-1000.

  48. Leech J, Önal E, Aronson R, Lopata M. Voluntary hyperventilation in obesity hypoventilation. Chest. 1991;100(5):1334-8.

  49. Hoeper MM, Barberá JA, Channick RN, Hassoun PM, Lang IM, Manes A, et al. Diagnosis, assessment, and treatment of non-pulmonary arterial hypertension pulmonary hypertension. J Am Coll Cardiol. 2009;54(1 Suppl):S85-96.




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