Quero-Hernández A, Quero-Estrada A, Sánchez-Navarro LM, Reyes-Hernández KL, Hernández-Arriola J, Reyes-GómezU

Language: Spanish
References: 19
Page: 119-126
PDF size: 845.54 Kb.

ABSTRACT

Cutaneous melanoma is a highly aggressive tumor. Congenital malignant melanoma is extremely rare. The objective is to present the case of an infant with congenital melanoma.
A 1.5-year-old male, who at 5 months of age noticed increased nodular volume on the border of a melanocytic nevus, ulceration and bleeding in the right occipital region, did not receive medical care for a year. He was in poor general condition with respiratory difficulty. An insicional biopsy with a malignant melanoma report thickness greater than 4mm and positive pleural fluid. Extension studies with generalized lymphadenopathy, infiltration of pulmonary and hepatic parenchyma, died within 8 days of admission.
The aggressiveness of congenital melanomas seems to be due to activation in the mutation of NRAS Q61, without alteration of pTERT and NRAS, an alteration that is common in giant CMNs that evolve to malignant melanoma and imply a precarious survival.
We emphasize that before any skin lesion that undergoes changes in color, borders, ulceration requires dermoscopic evaluation to offer a diagnosis and timely treatment

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