Juárez-Nieto OJ, Gutiérrez-González J

Language: Spanish
References: 0
Page: 228-234
PDF size: 145.51 Kb.

ABSTRACT

Background: Head and neck epidermoid cancer represents a significant cause of worldwide morbidity, the most common anatomical subsites for this type of carcinoma are the larynx, oral cavity and oropharynx. In recent years there has been a decrease related to traditional risk factors: alcohol and tobacco, and an increase in the incidence related to the presence of HPV (human papilloma virus), causing an impact on the biological and clinical form, and on the management and prevention strategies.
Objective: To determine the prevalence in patients with diagnosis of oropharyngeal squamous cell carcinoma in association with genotypes of HR-HPV (high risk human papilloma virus), especially genotype 16.
Material and Method: An ambispective, observational, transverse and descriptive study of 5 years (2011-2015), carried out in patients from the Hospital Juárez de México, in which we performed determination of DNA and microarrays for detection of HPV, from fresh tissue biopsies of patients with suspicious clinical lesions and paraffin-embedded tissue in patients diagnosed with oropharyngeal squamous cell carcinoma.
Results: There were 10 men and 5 women; the range age varied from 44 to 78 years, the distribution of lesions was 87% in tonsils and 13% in the base of tongue. The percentage of cases in which HPV16 DNA was detected was 13.3%.
Conclusions: The incidence of human papilloma virus and squamous cell carcinoma in oropharynx is low in our population.