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ISSN 1995-9494 (Electronic)
Revista del Hospital Clínico Quirúrgico "Arnaldo Milián Castro"

2018, Number 1

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Acta Med Cent 2018; 12 (1)

Comportamiento del virus de hepatitis C en pacientes hemodializados

Medellín RH, González GEL, Arce NM, Moré PA, López MVM, Echevarria GY

Language: Spanish
References: 30
Page: 19-28
PDF size: 281.57 Kb.


ABSTRACT

Introduction: infection with hepatitis C virus is frequent in patients with chronic renal failure with or without hemodialysis treatment; in them this pathogen is the main cause of liver disease. Objectives: to describe epidemiological, clinical, endoscopic and histological aspects of the liver in a group of patients with chronic renal insufficiency in a hemodialysis regime suffering from hepatitis C virus. Method: a descriptive and cross-sectional study was carried out between April 2015 and March 2016. The universe consisted of all patients 18 years and over, of both sexes, with chronic renal failure on a hemodialysis regimen suffering from hepatitis C virus, treated at the “Arnaldo Milián Castro” Hospital; the sample was 34 patients. Results: the greater number of affected corresponded to the range of 40 to 59 years of age (61,8%) and the male sex predominated (61,8%). A total of 23 patients (67,6%) had more than six years of evolution of the infection and the alanine aminotransferase was elevated in 26 (76,5%). Hepatomegaly was the clinical finding that predominated (20, 58,8%) and by laparoscopic examination (67,6%) and histological (83,3%) highlighted chronic hepatitis. Conclusions: infection by the hepatitis C virus was more frequent in the group of ages among 40 and 59 years and it predominated in men. The most important biochemical parameter was the elevation of alanine aminotransferase and in the clinical predominated the hepatomegaly. To longer time of infection, corresponded more time of hepatic affectation, both endoscopically and histologically.


REFERENCES

  1. Dubois F, Desenclos JC, Mariotte N, Goudeau A. Hepatitis C in a French population-based survey, 1994: seroprevalence, frequency of viremia, genotype distribution, and risk factors. The Collaborative Study Group. Hepatology. 1997;25:1490-96. PMID 9185773.

  2. Ministerio de Salud Pública. Anuario Estadístico de Salud 2011[Internet]. La Habana: Dirección Nacional de Estadística; 2012 [citado 13 Oct 2015]. 193 p. Disponible en: http://files.sld.cu/bvscuba/files/2012/05/anuario-2011-e.pdf

  3. Organización Mundial de la Salud. Estadísticas Sanitarias Mundiales, Datos del observatorio mundial de Salud [Internet]. 2012 [citado 13 Oct 2015]. 178 p. Disponible en: http://www.who.int/gho/publications/world_health_statistics/2012/es/

  4. Marinovich S, Lavorato C, Bisigniano L, Soratti M, Hansen Krogh D. Registro Argentino de Diálisis Crónica SAN-INCUCAI 2011. Informe 2012. Rev Nefrol Argentina [Internet]. 2013 [citado 13 Oct 2015];11(2):71-127. Disponible en: https://www.incucai.gov.ar/files/docs-incucai/Materiales/informes-estadisticos/15-registro_arg_dialisis_2012.pdf

  5. Di Filippo D, Cortes-Mancera F, Beltran M, Arbelaez MP, JaramilloS, Restrepo JC, et al. Molecular characterization of hepati-tis c virus in multi-transfused Colombian patients. Virol J [Internet]. 2012 [citado 21 Dic 2016];9:242. Disponible en: https://virologyj.biomedcentral.com/articles/10.1186/1743-422X-9-242

  6. Schaefer M, Capuron L, Friebe A, Diez-Quevedo C, Robaeys G, Neri S, et al. Hepatitis C infection, antiviral treatment and mental health: a European expert consensus statement. J Hepatol. 2012 Dec;57(6):1379-90. doi: 10.1016/j.jhep.2012.07.037

  7. Sarrazin C, Hezode C, Zeuzem S, Pawlotsky JM. Antiviral strategies in hepatitis C virus infection. J Hepatol. 2012;56(Suppl 1):S88-S100. doi: 10.1016/S0168-8278(12)60010-5.

  8. Da Silva NM, Germano FN, Mendoza-Sassi RA, Seuánez HN, Soares MA, de Martínez AM. Evidence of association betweenhepatitis C virus genotype 2 b and nosocomial transmission sin hemodialysis centers from southern Brazil. Virol J. 2013 May 29;10:167. doi.org/10.1186/1743-422 X-10-167.

  9. Sulkowski MS, Gardiner DF, Rodríguez-Torres M, Reddy KR, Hassanein T, Jacobson I, et al. Daclatasvir plus Sofosbuvir for Previously Treated or Untreated Chronic HCV Infection. N Engl J Med. 2014 Jan 16;370(3): 211-21. doi: 10.1056/NEJMoa1306218.

  10. 10.Nesseler N, Launey Y, Aninat C, Morel F, Mallédant Y, Seguin P. Clinical review: The liver in sepsis. Crit Care. 2012 Oct 30;16(5):235. doi: 10.1186/cc11381.

  11. 11.Gaite LA, Marciano S, Galdame OA, Gadano AC. Hepatitis C in Argentina: Epidemiology and treatment. Hepat Med [Internet]. 2014 May 27 [citado 21 Dic 2016];6:35-43. Disponible en: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4043810/

  12. 12.Chiesa IJ, Serafino JJ, García MG, Núñez G, Pérez MS, Pirola DA. Distribución de genotipos del virus de hepatitis C en la población Argentina. Acta Bioquím Clín. Latinoam [Internet]. 2012 [citado 21 Dic 2016];46(4):633-7. Disponible en: http://www.scielo.org.ar/pdf/abcl/v46n4/v46n4a05.pdf

  13. 13.Simmonds P. The origin of hepatitis C virus. Curr Top Microbiol Immunol. 2013;369:1-15. doi.org/10.1007/978-3-642-27340-7_1.

  14. 14.Smith DB, Bukh J, Kuiken C, Muerhoff AS, Rice CM, Stapleton JT, et al. Expanded classification of hepatitis C virus into 7 genoty-pes and 67 subtypes: Updated criteria and genotype assignmentWeb resource. Hepatology. 2014 Jan;59(1):318-27. doi.org/10.1002/hep.26744.

  15. 15.Nodarse CH, Arús SE, Rivera-Reimón LL, Pérez LM, Samada S, García F, et al. Interferón alfa-2b y ribavirina como tratamiento combinado para la hepatitis C crónica en Cuba: Programa Nacional. Biotecnol Aplic [Internet]. 2012 [citado 21 Dic 2016];29(3):184-88. Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S1027-28522012000300005

  16. 16.Westbrook RH, Dusheiko G. Natural history of hepatitis C. J Hepatol. 2014 Nov;61(1 Suppl):S58-68. doi: 10.1016/j.jhep.2014.07.012. Epub 2014 Nov 3.

  17. 17.Silva M, Ridruejo E, Galdame O, Bessone F, Colombato L. Recomendaciones para el tratamiento de la hepatitis crónica por virus C genotipo 1. Acta Gastroenterol Latinoam [Internet]. 2012 [citado 21 Dic 2016];42:234-249. Disponible en: http://www.redalyc.org/html/1993/199324184018/

  18. 18.Jadoul M, Barril G. Hepatitis C in hemodialysis: Epidemiology and prevention of hepatitis C virus transmission. Contrib Nephrol. 2012;176:35-41. doi: 10.1159/000333761. Epub 2012 Jan 30.

  19. 19.Praga M, Gutiérrez E, Morales E. Hepatitis C induced renal disease in patients with AIDS: An emergent problem. Contrib Nephrol. 2012;176:24-34. doi.org/10.1159/000332376.

  20. 20.Pawlotsky JM. The results of phase III clinical trials with Telaprevir and Boceprevir presented in the Liver Meeting 2010: A new standard of care for hepatitis C virus genotype 1 infection, but with issues still pending. Gastroenterology. 2011 Mar;140(3):746-54. doi: 10.1053/j.gastro.2011.01.028. Epub 2011 Jan 1.

  21. 21.Backus LI, Boothroyd DB, Phillips BR, Belperio P, Halloran J, Mole LA. A sustained virologic response reduces risk of all-cause mortality in patients with hepatitis C. Clin Gastroenterol Hepatol. 2011 Jun;9(6):509-516.e1. doi:10.1016/j.cgh.2011.03.004. Epub 2011 Mar 11.

  22. 22.Beinhardt S, Aberle JH, Strasser M, Dulic-Lakovic E, Maieron A, Kreil A, et al. Serum level of inhibidores de proteasa-10 increases predictive value of IL28B polymorphisms for spontaneous clearance of acute HCV infection. Gastroenterology [Internet]. 2012 Jan [citado 21 Dic 2016];142(1):78-85 e2. Disponible en: http://metcorner.gastro.org/article/S0016-5085%2811%2901332-1/abstract

  23. 23.Chayama K, Takahashi S, Toyota J, Karino Y, Ikeda K, Ishikawa H. Dual therapy with the nonstructural protein 5A inhibitor, daclatasvir, and the nonstructural protein 3 protease inhibitor, asunaprevir, in hepatitis C virus genotype 1b-infected null responders. Hepatology. 2012 Mar;55(3):742-8. doi: 10.1002/hep.24724. Epub 2012 Jan 30.

  24. 24.Crespo G, Lens S. Use of boceprevir and telaprevir in patientswith hepatitis C virus infection (practical considerations). Gastroenterol Hepatol. 2012 May;35(5):337-43. doi: 10.1016/j.gastrohep.2011.12.005. Epub 2012 Feb 19.

  25. 25.Gane EJ, Stedman CA, Hyland RH, Ding X, Svarovskaia E, Symonds WT, et al. Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C. N Engl J Med. 2013 Jan 3;368(1):34-44. doi: 10.1056/NEJMoa1208953.

  26. 26.Hasosah MY, Kutbi SY, Al-Amri AW. Perinatal cytomegalovirus hepatitis in Saudi infants: a case series. Saudi J Gastroenterol. 2012 May-Jun;18(3):208-13. doi: 10.4103/1319-3767.96461.

  27. 27.Lange C, Sarrazin C. Diagnostics Tests in Acute and chronichepatitis C. In: Mauss S, Berg T, Rockstroh J, Sarrazin C, Wedemeyer H. Short Guide to hepatitis C. Germany: Flying Publisher; 2012.

  28. 28.Lange C, Sarrazin C. New Drugs. In: Mauss S, Berg T, Rockstroh J, Sarrazin C, Wedemeyer H. Short Guide to hepatitis C. Germany: Flying Publisher; 2012.

  29. 29.Guerrero Peña BA. Comportamiento del virus de la hepatitis C en una población de adultos que acuden a la consulta médica del hospital Escuela Dr. Roberto Calderón Gutiérrez en los meses de Julio y Agosto del 2014 [Tesis]. Managua: Universidad Nacional Autónoma de Nicaragua; 2016.

  30. 30.Lok AS, Gardiner DF, Lawitz E, Martorell C, Everson GT, Ghalib, R, et al. Preliminary study of two antiviral agents for hepatitis C genotype 1. N Engl J Med. 2012 Jan 19;366(3):216-24. doi: 10.1056/NEJMoa1104430.




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