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Publicación cuatrimestral editada por la Secretaría de Salud Jalisco

2016, Number 1

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Sal Jal 2016; 3 (1)

Experiencia con el uso de inhibidor de la proteína quinasa C (tamoxifeno) en la manía: Reporte de caso

Aldana-López JA, Medina-Dávalos R

Language: Spanish
References: 30
Page: 54-59
PDF size: 308.21 Kb.


ABSTRACT

The conventional treatment for manic episodes in Bipolar Disorder (BD), oft en carry tolerability, safety and poor outcome problems, thus making necessary the development and investigation of new therapeutic agents that are based on physiopathological approaches of BD. Th e protein kinase C (PKC), intracelular signaling pathways has implications in BD, and tamoxifen, as a direct inhibitor, is one of the novel pharmaceutical agents for manic episodes. We describe the experience in the use of tamoxifen in a patient with BD in a manic episode, discussing the action mecanism and comparing its` clinical use, therapeutic response and adverse eff ects with documented literature.


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