Giacaman A, Escalas TJ, Bauzá AA, Martín-Santiago A

Language: English
References: 9
Page: 237-239
PDF size: 278.86 Kb.

ABSTRACT

Mastocytosis comprises a heterogeneous group of disorders characterized by mast cell proliferation and accumulation within various organs, most commonly the skin. Treatment of cutaneous mastocytosis is aimed at reducing symptoms, avoiding agents that precipitate mediator release, use of antihistamines, glucocorticoids, sodium cromoglycate and ketotifen. Phototherapy with UVA or UVB has proven effective in controlling pruritus and cutaneous wheals, and reducing the number of mast cells in the affected skin, but to date there are few pediatric cases reported in the literature. We present a case of a four-year-old girl with a nodular cutaneous mastocytosis and systemic symptoms with minimal response to previous therapies. The patient tolerated well the treatment with PUVA, achieving an improvement in her systemic symptoms, skin lesions, and quality of life, with no immediate side effects. Although the experience reported in the literature is limited and the long-term effects are not known, we propose that PUVA could be a useful alternative in severe cases of cutaneous mastocytosis in children.

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