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Coordinación General de Investigación de la Facultad de Salud Pública y Nutrición y la Dirección General de Sistemas e Informática de la Universidad Autónoma de Nuevo León

2005, Number 1

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Rev Salud Publica Nutr 2005; 6 (1)

Genetic variation of the human immunodeficiency virus: A general perspective

Rivera-Morales LG, Luna-Cruz IE, Ramos-Alfano G, Ordaz SMI, Ramos-Jimenez J, López GP, Tamez-Guerra R, Rodriguez-Padilla C

Language: Spanish
References: 33
Page:
PDF size: 811.75 Kb.


ABSTRACT

Acquired Immunodeficiency Syndrome is considered to be a pandemic now spreading widely throughout every country, effective diagnostic, surveillance and treatment measures are needed to curtail this epidemic. In Mexico, as in the rest of the world, AIDS has become a serious public health threat, in spite of every effort made to divulge epidemiologic, diagnostic, treatment and prevention knowledge aimed to curtail this disease, the actual number of cases is higher than the number reckoned by health authorities, hence the socioeconomical consequences are dire. HIV-1 is a virus exhibiting a high degree of genetic variation, which brings about changes in virus tropism, virulence and transmissibility. New variants and/or HIV-1 subtypes are currently circulating with a wide range of properties regarding virulence and transmission, spreading throughout the world in an ever increasing manner. The HIV-1 subtype B is the predominant virus in the AIDS epidemic in Mexico, but not exclude the presence of other subtypes in the country, as the presence of subtype C in a sudafrican individual. An adecuate epidemiologic surveillance for HIV-1/ AIDS including identification, characterization and analysis of predominant strains to evaluate its genetic diversity must be carried out in our country, in an effort leading to ascertain geographic distribution patterns to better understand the dissemination, epidemiology antiviral drug development and vaccine design.


REFERENCES

  1. Gottieb MS, R. Schorf, H.M.Schanker, et al. 1981. Pneumocystis carinii pneumonia and mucosal candidiasis in previously healthy homosexual men. N. Engl. J. Med. 305: 1425 - 1431.

  2. Resumen Mundial de la Epidemia del VIH / SIDA . 2003. Organización Mundial de la Salud, ONUSIDA.

  3. Secretaría de Salud (SSA) y Centro Nacional para la prevención y control del VIH/SIDA (CENSIDA). Epidemiología del VIH/SIDA en México en el año 2003.

  4. Idem.

  5. Strebel K. and S. Bour. 1999. Molecular interactions of HIV with host factors. AIDS. 13 (suppl A):S13 – S24

  6. Idem.

  7. HIV SÉQUENSE DATABASE http://www.hiv.lanl.gov/content/hiv-db/mainpage.html

  8. Kanki P. 1996. Epidemiology and Natural History of HIV-2. AIDS: Etiology, Diagnosis, Treatment and Prevention. V. DeVita, S. Hellman, and S. Rosenberg, Ed. J. B. Lippincott Co. Philadelphia. 97-108.

  9. Markovitz, D.M. 1993. Infection with the Human Immunodeficiency Virus Type 2. Annals of Internal Medicine.118(3): 211-218

  10. Shanmugam V., W.M. Switzer, J.N. Nkengasong, G. Garcia-Lerma, T.A. Green, E. Ekpini, M. Sassan-Morokro, F. Antunes, K. Manshino, V. Soriano, S.Z. Wiktor, W. Heneine. 2000. Lower HIV-2 plasma viral loads may explain differences between the natural histories of HIV-1 and HIV-2 infections. J. Acquir Immune Defic Syndr. 24 (3). 257 - 263

  11. Leitner, T., B. Foley, B. Hahn, F. McCutchan, P. Marx, S. Wolinsky, J. Mellors, J. Moore, B. Korber. 2004. Human Retroviruses and AIDS. Los Alamos National Laboratory.

  12. Yamaguchi J., A. Vallari, P. Swanson, P. Bodelle, L. Kaptue, C. Ngansop, L. Zekeng, L.G. Gurtler, S.G. Devare, C.A. Brennan. 2002. Evaluation of HIV type 1 group O isolates: identification of five phylogenetic clusters. AIDS Res Hum Retroviruses. 18 (4):269 - 82

  13. Kanki PJ, D.J. Hamel, J.L. Sankale, C. Hsieh, I. Thior, F. Barin, S.A. Woodcock, A. Gueye-Ndiaye, E. Zhang, M.Montano, T. Siby, R. Marlink, I. NDoye, M. Essex, S. MBoup. 1999. Human immunodeficiency virus type 1 subtypes differ in disease progression. J Infect Dis 179: 68 - 73.

  14. Burke, D. S. and F. E. McCutchan. 1997. Global distribution of human immunodeficiency virus type 1 clades. AIDS: Biology, Diagnostics, Treatment and Prevention. Ed. Lippincott-Raven Publishers, New York. 119 – 126.

  15. Crandall K.A., D.A. Vasco, D. Posada and H. Imamichi. 1999. Advances in understanding the evolution of HIV. AIDS. 13 (suppl): S39 – S47.

  16. Roberts, J. D., K. Bedenek, and T. A. Kunkel. 1988. The accuracy of reverse transcription from HIV-1. Science. 242:1171 - 1173.

  17. Kanki PJ. Op cit.

  18. Montano, M.A., C.P. Nixon, T. Ndungu, H. Bussmann, S. Gaolekwe, D. Dickman, V. Novitsky, and M. Essex. 2000. Elevated TNF-alpha activation of HIV-1 subtype C in southern Africa associated with an NF-kappaB enhancer gain-of-function. J Infect Dis.181: 76 – 81.

  19. Yamaguchi J.Op cit

  20. Burke, D.S. 1997. Recombination in HIV: An Important Viral Evolutionary Strategy. Emerging Infectious Disease. 3(3): 253 – 259.

  21. HIV SÉQUENSE DATABASE . Op cit

  22. Howard, T.M., D.O. Olaylele, S. Rasheed. 1994. Sequence analysis of the glycoprotein 120 coding region of a new HIV type 1 subtype A strain (HIV-1IbNg) from Nigeria. AIDS Res. Hum. Retroviruses. 10(12): 1755 – 1757.

  23. Dowling, W.E., B. Kim, C.J. Mason, K.M. Wasunna,M.onique, Alam, U.,Elson, L., Birx, D.L., Robb, M.L., McCutchan, F.E., Carr, J.K. 2002. Forty-one near full-length HIV-1 sequences from Kenya reveal an epidemic of subtype A and A-containing recombinants. AIDS 16(13): 1809 -1820.

  24. HIV SÉQUENSE DATABASE . Op cit

  25. Vazquez-Walls E, R. Cheingsong-Popov, J.J. Sierra-Quevedo, S. Lister, F. Lopez-Marquez, J. Weber, L. Zuniga-Gonzalez, P. Campos-Lopez and J. Esparza. 1996. Monotypic HIV-1 subtype B in Guadalajara, México. XI International AIDS Conference, Vancouver,Canada. (Abstract 2070).

  26. Vasquez-Walls E, J.J. Sierra-G, F.C. Lopez-Marquez, M. Escoto-Delgadillo, M.C. Lopez-Lomeli and P.I. Campos-Lopez. 1998. No differences in Mexico between HIV-1 subtype B, sexual preferences and routes of transmission.12th World AIDS Conference, Geneva, Switzerland. (Abstract 11180).

  27. Gudino JC, F. Martinez, P. Alcantara and C. Soler. 1996. Genotyping of Mexican HIV-1 isolates. XI International AIDS Conference, Vancouver, Canada. (Abstract 2071).

  28. Soler Claudin C and J.C. Gudino Rosales. 1998. Subtyping of HIV-1 in Mexico by envHMA and gagPCR-FLP. 12th International AIDS Conference, Geneva, Switzerland. (Abstract 11198).

  29. Vazquez-Walls E, R. Op cit.

  30. Rivera-Morales,L.G., V.A. Novitsky, J.R. Trujillo, C. Lavalle-Montalvo, C. Cano-Dominguez, J. Ramos-Jimenez, E. Jimenez-Rios, L. Flores-Flores, P. Lopez-Guillen, P. Gilbert, F. Vannberg, R.S. Tamez-Guerra, C. Rodriguez-Padilla, and M. Essex. 2001. The Molecular Epidemiology of HIV Type 1 of Men in México. AIDS Res Human Retroviruses. 17(1); 87 - 91.

  31. Pieniazek D, C. Yang and R.B. Lal. 1998. Phylogenetic analysis of gp41 envelope of HIV-1 groups M, N, and O. Human Retroviruses and AIDS. Theoretical Biology and Biophysics, Group T-10. Los Alamos National Laboratory. Part III-112 - 117.

  32. Rivera-Morales L,G., V.A. Novitsky, I.E. Luna-Cruz, G. Ramos-Alfano, J. Ramos-Jimenez, P. Lopez-Guillen, M. Essex, R.S. Tamez-Guerra y C. Rodriguez-Padilla. 2003. Molecular epidemiology of HIV-1 in Mexico; new subtype found in Mexico. The 2nd IAS Conference on HIV Pathogenesis and Treatment, Paris, Francia. (Abstract LB 34).

  33. Scott J. and B.H. Hahn. 1999. Vaccines and immunology. AIDS. 13(suppl): S103 – S104




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