Pérez CN, Martínez TMC, Díaz MI

Language: Spanish
References: 0
Page: 381-394
PDF size: 134.47 Kb.

ABSTRACT

Introduction: mutations in the structure and the function of the ion channels have been called channelopathies and their implication in a number of clinical diseases such as the chronic pain syndromes have been studied. Objective: to describe the main mutations in the ion channels that give rise to pain syndromes and represent therapy targets for new analgesic drugs. Methods: a literature review was made through the PubMed website and the academic search engine Google, by using the key words pain and channelopathies. The association of these terms yielded 737 and 4 500 bibliographic citations, respectively in English and Spanish of which 44 publications from open access journals were consulted. Development: mutations in potassium, sodium, calcium channels and in transient potential receptors have been related to neuropathic pain, inflammatory pain and pain caused by cancer, mainly in pathologies such as neuropathic hyperalgesia, extreme paroxystic pain, primary erythromelalgia, congenital insensitivity to pain, migraine and periodic hypopotassium paralysis. Final thoughts: the central role of channelopathies in chronic pain indicates new analgesic therapeutic targets for agonist or antagonist pharmaceuticals with higher selectivity of action, which could contribute to personalized prescription and higher efficacy and safety, and thus a greater use of these new analgesics for treatment of all age groups.