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2017, Number 2

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Rev Cubana Hematol Inmunol Hemoter 2017; 33 (2)

Radioisotopic image: an efficient tool in regenerative therapy

Hernández RLH, Fundora STA, Janero VA, Hernández RP

Language: Spanish
References: 28
Page: 1-9
PDF size: 159.04 Kb.


ABSTRACT

Regenerative therapy is nowadays a promising alternative treatment for many diseases. The utility of radioisotope image technologies in assessing of the efficiency and security of stem cell therapies is described. We present some of the facts that led to development of the nuclear medicine image technology, as well as the general characteristics of single photon emission computed tomography and positron emission tomography. It was also included application of radioisotope images in the evaluation of biodistribution changes, flow and perfusion in anatomical affected zones by different diseases, in the fields of angiology, orthopedia and cardiology, as a result of the regenerative and proliferative effects induced by stem cells transplant. We mention the radiopharmaceuticals and labelled molecules used in the evaluation of angiogenesis and lymph angiogenesis resulting of cellular therapy and the radioisotopes markers that allow tracking of transplanted stem cells.


REFERENCES

  1. Rodriguez Carvajal J. Neuroimagen funcional. Combinación de anatomía y fisiología. Gac Méd Méx. 2002;38(3):247-57.

  2. Ruano Aguilar JM, Palafox Sánchez R, García Buenrostro N. Utilidad de la tomografía por emisión de positrones combinada con tomografía computarizada en oncología pediátrica. Acta Médica. 2006;4(3):154-63.

  3. Aparicio Suárez JL. Madre de una medicina que emerge. Rev Cubana Hematol Inmunol Hemoter. 2011 Sep;27(3):271-2.

  4. Hernández Ramírez P. Medicina regenerativa y células madre. Mecanismos de acción de las células madre adultas. Rev Cubana Hematol Inmunol Hemoter [Internet]. 2009 Abr [citado 2016 Jun 30];25( 1 ): Disponible en: http://scielo.sld.cu/scielo.php?script=sci_arttext&pid=S0864- 02892009000100002&lng=es .

  5. Hernández Ramírez P, Dorticós Balea E. Tras la huella de las células madre. Rev Cubana Hematol Inmunol Hemoter. 2010 Ago;26(2):18-22.

  6. Beeres S, Bengel FM, Bartunek J, Atsma D, Hill J, Vanderheyden M, et al. Role of Imaging in Cardiac Stem Cell Therapy. J Am Coll Cardiol. 2007 Mar 20;49(11):1137-48.

  7. Padilla L, Rodríguez-Trejo JM, Gasca O, Carranza P, Martínez LA, Mota E, et al. Técnica para evaluar neovascularización o angiogénesis experimental en la extremidad isquémica de la rata. Rev Mex Angiol. 2014;24(3):115-8

  8. Mitchel R, Wunan Z, Albert J. Radiotracer Imaging of Peripheral Vascular Disease. J Nucl Med Technol . 2015;43:185-92.

  9. Nicole A, Yingli F Jeremy M, Kraitchman D. Tracking of stem cells in vivo for cardiovascular applications. J Cardiovasc Magn Reson. 2014 Jan 10;16:7. doi: 10.1186/1532-429X-16-7.

  10. Hernández-Ramírez P, Alfonso-Simón A, Aparicio-Suárez JL, Artaza-Sanz H, Baganet- Cobas A, Blanco-Díaz Á, et al. Experiencia cubana con el uso terapéutico de células madre adultas. Rev Cubana Hematol Inmunol Hemoter. 2011 -Mar;27(1):91-108.

  11. Peña Quián Y, Hernández Ramírez P, Batista Cuellar JF, Perera Pintado A, Coca Pérez MA. Lymphoscintigraphy for the Assessment of Autologous Stem Cell Implantation in Chronic Lymphedema. Clin Nucl Med. 2015 Mar;40(3):217-9. doi: 10.1097/RLU.0000000000000688.

  12. Terzic A, Perez-Terzic C.Terapia celular para la insuficiencia cardiaca. Rev Esp Cardiol. 2010;63(10):1117-9.

  13. Beeres S, Bengel F, Bartunek J, Hill J, Vanderheyden M, Penicka M, et al. Role of Imaging in Cardiac Stem Cell Therapy. J Am Col Cardiol. 2007;49 (11):1037-48.

  14. Solanki K, Dondi M. Radiolabelled autologous cells: methods and standardization for clinical use. 5ta ed. VIENNA: Sales Unit, Publishing Section International Atomic Energy Agency; 2015.p. 7-8.

  15. Zhang W, Xiao-Cheng L, Yang L, De-Lin Z, Dong Zhang Y, Chen Y, et al. Wharton's jelly-derived mesenchymal stem cells promote myocardial regeneration and cardiac repair after miniswine acute myocardial infarction. Coron Artery Dis. 2013 Nov;24(7):549-58. doi: 10.1097/MCA.0b013e3283640f00.

  16. Peix A, Hidalgo J, Dorticós E, Llerena L, Paredes A, Torres M, et al. Reparación del miocardio mediante la terapia con células madre. Article No AJ 32-1 Alasbimn J. 2006;8(32): [citado 10 julio 2009] Disponible en: http://www2.alasbimnjournal.cl/alasbimn/CDA/sec_b/0,1206,SCID%253D16340,00.html

  17. Feito Castex T, Perurena Llamosa C, Aparicio Suárez JL, Bustillo Santandreu MJ, García Seco F. Implante de células madre hematopoyéticas en pacientes con isquemia crónica de los miembros inferiores. Rev Cubana Angiol Cir Vasc. 2015 Jun;16(1):64-75.

  18. Lasala G, Silva J, Garner P, Minguell. Combination Stem Cell Therapy for the Treatment of Severe Limb Ischemia: Safety and Efficacy Analysis. Angiology. 2010; 61(6):551-6.

  19. Shuhei T, Miyamoto M, Takagy G, Fukushima Y, Kirinoki S, Hitoshi T, et al. Prediction of Limb Salvage after Therapeutic Angiogenesis by Autologous Bone Marrow Cell Implantation in Patients with Critical Limb Ischemia. Ann Vasc Dis. 2011; 4(1):24-31.

  20. Nizankowski R, Petriczek T, Skotnicki A, Szczeklik A. The treatment of advanced chronic lower limb ischaemia with marrow stem cell autotransplantation. Kardiol Pol. 2005;63:351-60.

  21. Surikaya A, Husamettin T, Cemal A, Benlier E, Unal Y. Predictive value of 99mTcsestamibi scintigraphy for healing of extremity amputation. Eur J Nucl Med Mol Imaging. 2006;33(12):1500-7.

  22. Morrison AR, Albert J. Advances in radionuclide molecular imaging in myocardial biology. J Nucl Cardiol. 2010;17(1):116-34

  23. Erxiong L, William R, Schellenberger U, Abraham J, Klibanov A, Woulfe S, et al. Targeted In Vivo Labeling of Receptors for Vascular Endothelial Growth Factor. Circulation. 2003;108:97-103.

  24. Gaertner FC, Kessler H, Wester HJ, Schwaiger M, Beer AJ. Radiolabelled RGD peptides for imaging and therapy. Eur J Nucl Med Mol Imaging. 2012;39 (Suppl 1):S126-38.

  25. Burnand KM, Sundaraiya S, Glass D, Mortimer PS, Peters AM Visualisation of popliteal nodes in lymphoscintigraphy is abnormal. Nucl Med Commun. 2010;31:437-47

  26. Tartaglione G. Intradermal lymphoscintigraphy at rest and after exercise: a new technique for the functional assessment of the lymphatic system in patients with lymphoedema. Nucl Med Commun. 2010;31(6):547-51.

  27. Gangji V, Philippe Hauzeu J. Treatment of Osteonecrosis of the Femoral Head with Implantation of Autologous Bone-Marrow Cells. J Bone Joint Surg Am. 2005;87:106- 112. doi:10.2106/JBJS.D.02662

  28. Hernández Ramírez P. Décimo aniversario del fructífero empleo de la medicina regenerativa en Cuba. Rev Cubana Hematol Inmunol Hemoter. 2015 Sep;31(3):221-5.




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