medigraphic.com
ISSN 0210-5187 (Electronic)

2004, Number 5

<< Back Next >>

Med Cutan Iber Lat Am 2004; 32 (5)

Intralesional 5-Fluorouracil: A New Approach for Recalcitrant and Periungual Warts

Zanini M, D´Apparecida SMC

Language: Portugués
References: 13
Page: 201-204
PDF size: 303.34 Kb.


Text Extraction

We report the use of intralesional 5-fluorouracil (5FU) in the treatment of recalcitrant and periungual warts in an open-label study of 33 patients. Twenty-eight patients (84,8%) presented clinical cure (ρ < 0,001). Intralesional 5FU therapy appears to be a beneficial and safe treatment for this disease.


REFERENCES

  1. Sterling JC, Handfield-Jones S, Hudson PM. Guidelines for the management of cutaneous warts. Br J Dermatol 2001; 144: 4-11.

  2. Tosti A, Piraccini BM. Warts of the nail unit: surgical and nonsurgical approaches. Dermatol Surg 2001; 27: 235-9.

  3. Naylor M. Cutaneous human papillomavirus infections. Available at: http://telemedicine.org/warts/cutmanhpv.htm. Accessed December 15, 2002.

  4. Torrelo A. What’s new in the treatment of viral warts in children. Pediatr Dermatol 2002; 19: 191-9.

  5. Hayes ME, O’Keefe EJ. Reduced dose of bleomycin in the treatment of recalcitrant warts. J Am Acad Dermatol 1986; 15: 1002-6.

  6. Robson KJ, Cunningham NM, Kruzan KL, et al. Pulsed-dye laser versus conventional therapy in the treatment of warts: A prospective randomized trial. J Am Acad Dermatol 2000;43: 275-80.

  7. Pfau A, Abd-el-Raheem TA, Bäumler W, Hohenleutner U, et al. Nd: YAG laser hyperthermia in the treatment of recalcitrant verrucae vulgares (Regensburg’s technique). Acta Derm Venereol 1994; 74: 212-4.

  8. Tyring SK. Human papillomavirus infections: epidemiology, pathogenesis, and host immune response. J Am Acad Dermatol 2000; 43: 18-26.

  9. National drug data file. Avaliable At: http://www.medscape.com/druginfo. Accessed December 14, 2002.

  10. Senff H, Reinel D, Mathhies C, Witts D. Topical 5-fluorouracil solution in the treatment of warts – clinical experience ans percutaneous absorption. Br J Dermatol 1988; 118: 409-14.

  11. Munn SE, Higgins E, Marshall M, Clement M. A new method of intralesional bleomycin therapy in the treatment of recalcitrant warts. Br J Dermatol 1996; 135: 969-71.

  12. Stanley M, Coleman N, Chambers M. The host response to lesions induced by human papillomavirus. Ciba Found Symp 1994; 187: 21-32; discussion 32-44.

  13. Fitzpatrick RE. Treatment of inflamed hypertrofic scars using intralesional 5-FU. Dermatol Surg 1999; 25: 224-32.




2020     |     www.medigraphic.com