2017, Number 11
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Ginecol Obstet Mex 2017; 85 (11)
Molar pregnancy with live fetus, and perinatal success. Case report and bibliographical review
Muciño-García E, Hinojosa-Rodríguez KA, López-Rioja MJ, Salgado-Benítez E, Pérez-Lara SA, Zebadúa-Jiménez VH, López-Recio Y
Language: Spanish
References: 26
Page: 772-777
PDF size: 360.29 Kb.
ABSTRACT
Background: The partial or incomplete mole represents 30% of
gestational trophoblastic diseases. However, the incidence of partial
mole with a viable fetus is an uncommon presentation, with an incidence
of 1 per 100,000 pregnancies.
Case Report: a 27-year-old female with a gyneco-obstetric history
of 3 pregnancies and 2 births, without comorbidities or alterations of
importance for the current condition; pregnancy of 30.1 weeks according
to the date of last menstruation and diagnosis of gestational
trophoblastic disease (partial spring), placenta previa and arcuate
uterus. The ultrasound evidenced hydropic vesicles, compatible with
gestational trophoblastic disease (incomplete mole). The amniocentesis
was performed at 16.3 weeks of pregnancy. The karyotype 46, XX
was found. It was decided to terminate the pregnancy by emergency
cesarean section. Since it was a pregnancy with high morbidity and
mortality, and the patient had parity satisfied, it was decided to perform
a cesarean-hysterectomy using the Esperanza-Bautista technique. A
female newborn was born, weighing 1416 g, Capurro 3 weeks and
APGAR 7/9. The pathology report was abnormal proliferation of the
trophoblast, vesicles and villi. At the moment the patient remains in
weekly follow-up with no apparent complications.
Conclusions: Molar pregnancy with a viable fetus has an infrequent
presentation. Early diagnosis, close prenatal follow-up, and
multidisciplinary management condition perinatal success.
REFERENCES
Candelier J. The hydatiform mole. Cell Adh Migr 2015;10:226-235.
Vassilakos P, Riotton G, Kajii T. Hydiform mole: two entities. A morphologic and cytogenetic study with some clinical consideration. Am J Obstet Gynecol 1977;127:167-170.
Szulman AE, Surti U. The clínico pathologic profile of the partial hydatidiform mole. Obstet Gynecol 1982;59:597- 602.
Szulman AE, Surti U. The syndromes of hydatidiform mole. I. Cytogenetic and morphologic correlations. Am J Obstet Gynecol 1978;131:665-671.
Kajii T, Ohama K. Androgenetic origin of hydatidiform mole. Nature 1977;268:633-634.
Berkowitz RS, Goldstein DP. Clinical practice. Molar pregnancy. N Engl J Med 2009; 360:1639-1645.
Berkowitz RS, Goldstein DP. Chorionic tumors. N Engl J Med 1996;335:1740-1748.
Yamashita K, Wake N, Araki T, et al. Human lymphocyte antigen expression in hydatidiform mole: androgenesis following fertilization by a haploid sperm. Am J Obstet Gynecol 1979;135:597-600.
Azuma C, Saji F, Tokugawa Y, et al. Application of gene amplification by polymerase chain reaction to genetic analysis of molar mitochondrial DNA: the detection of anuclear empty ovum as the cause of complete mole. Gynecol Oncol 1991;40:29-33.
Seckl MJ, Sebire NJ, Berkowitz RS. Gestational trophoblastic disease. Lancet 2010;376:717-729.
Arteaga GC. Ginecología y reproducción humana. Temas selectos. Tomo I. México: Colegio Mexicano de Especialistas en Ginecología y Obstetricia, 2006;631-637.
Lira P, Tenorio G, Gómez-Pedroso R, et al. Enfermedad trofoblástica gestacional: experiencia de 6 años en el Instituto Nacional de Perinatología. Ginecol Obstet Mex 1995;63:478-482.
Rahamni M, Parviz S. A case report of partial molar pregnancy associated with a normal appearing dizygotic fetus. Asian Paci J Reprod 2016;5:171-173.
Czernobilsky B, Barash A, Lance M. Partial Moles: a clinico-pathologic study of 25 cases. Obstet Gynecol 1982;59:75-77.
Sebire N, Foskett M, Paradinas F, et al. Outcome of twin pregnancies with complete hydatidiform mole and healthy co-twin. Lancet 2002;359:165-166.
Suzuki M, Matsunobu A, Vakita K, et al. Hydatidiform mole with surviving co-existent fetus. Ombt Gynecol 1980;56:384-388.
Vaisbuch E, Ben-Ariea A, Dgania R, et al. Twin pregnancy consisting of a complete hydatidiform mole and co- existent fetus: Report of two cases and review of literature. Gynecol Oncol 2005;98:9-23.
Changchien CC, Eng HL, Chen WJ. Twin pregnancy with hyda- tidiform mole (46,XX) and a coexistent fetus (46,XY): report of a case. J Formos Med Assoc 1994;93:337-339.
Sarno AP, Moorman AJ, Kalousek DK. Partial pregnancy with fetal survival: an unusual example of confined placental mosaicism. Obstet Gynecol 1993;82:716-719.
Shobhau N, Dhananjaya B, Sunil K et al. A Term Pregnancy with Partial Molar Changes : A Case Report. Int J Biol Med Res 2011; 2:1191-1192.
Vejerslev LO. Clinical management and diagnostic possibilities in hydatidiform mole with coexistent fetus. Obstet Gynecol Surv 1991;46:577-588.
Vaisbuch E, Ben-Ariea A, Dgania R, et al. Twin pregnancy consisting of a complete hydatidiform mole and coexistent fetus: Report of two cases and review of literature. Gynecol Oncol 2005;98:9-23.
Soper Jt, Match DG, Schink JC, et al. Diagnosis and treatment of gestational trophoblastic disease: ACOG Practice Bulletin No 53. Gynecol Oncol 2004;93:575-585.
Cavaliere A, Ermito S, Dinatale A, et al. Managment of molar preagnancy. J Prenat Med 2009;3:15-17.
Acien P. Reproductive performance of women with uterine malformations. Hum Reprod 1993;8:122-126.
Kohorn EI. The new FIGO 2000 staging and risk factor scoring system for gestational trophoblastic disease: description and clinical assessment. Int J Gynecol Cancer 2001;11:73-77.