2017, Number 2
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Rev Cuba Endoc 2017; 28 (2)
Thyroid-associated orbinopathy at pediatric ages
Maciques RJE, Pérez MME, Redondo PLR, Espinosa RT
Language: Spanish
References: 18
Page: 1-7
PDF size: 95.47 Kb.
ABSTRACT
Graves´ disease is rare in children and adolescents, and although it develops with a
fairly abundant clinic, this diagnosis is not always taken into account and in many
occasions, the patients are referred to the endocrinology service from the
psychology and /or psychiatry service because of predominant behavioral
alterations (hyperkinesia, irritability). This eye disease may appear, either
associated or not, to the conditions of hyperthyroidism, and it occurs many times in
the euthyroid patient, so it is presently called thyroid-associated orbinopathy. It is
an autoimmune, autolimited disease affecting the connective tissue and its
progression is less severe than in the adult. The treatment is very particularized at
pediatric ages because the therapeutic modalities as such do not meet all the
required effectiveness and safety criteria. Taking into account the degree and the
severity of orbinopathy, the respective care protocols are set. Generally speaking, it
is worthwhile to point out that at these ages; there are moderate or slight forms of
disease. There are also three lines of treatment: medication with synthesis antithyroid;
the radioiodine therapy alone or in combination with steroidal therapy; and
the surgical excision of the thyroid gland. It is very uncommon that a child
undergoes orbital surgery. The objective of this review was to reorganize updated
information about this topic.
REFERENCES
Chan W, Wong GW, Fan DS. Ophthalmopathy in childhood Graves's disease. Br J Ophthalmol. 2002;86:740-2.
Putta-Manohar S. Epidemiology of Graves's orbitopathy. Pediatr Endocrinol Rev. 2010;7(2):182-5.
Harold Lee HB, Rodgers IR, Woog JJ. Evaluation and management of Graves orbitopathy. Otolaryngol Clin North Am. 2006;39(5):923-42.
Pombo M. Tratado de Endocrinología Pediátrica. 4ta. ed. Capítulo 32. Hipertiroidismo. Madrid: Mc Graw Hill Interamericana; 2012. p. 385-90.
Pérez-Moreiras JV, Coloma-Bockos JE, Prada-Sánchez MC. Thyroid Orbitopathy Pathogenesis, Diagnosis and Treatment. Arch Soc Esp Oftalmol. 2003;78(8):407-31.
Santos M, Martínez N. Oftalmopatía tiroidea como inicial y única manifestación clínica de la enfermedad de Graves en una paciente en edad escolar. Rev Esp Endocrinol Pediatr. 2013;4(1):87-92.
Bartalena L, Baldeschi L, Dickinson A, Eckstein A, Kendall-Taylor P, Marcocci C, et al. Consensus statement of the European Group on Graves´orbitopathy (EUGOGO) on management of GO. Eur J Endocrinol. 2008;158(3):27-385.
Ponce de León E, Rodríguez L, Tovilla JL, Soto NV, Quiroz MA. Características clínicas y tomográficas en pacientes con orbitopatía tiroidea. Rev Mex Oftalmol. 2008;82(5):281-3.
Sandrini R, Nesi S, Lacerda L. Hipertiroidismo. En: Pombo Áreas M. Tratado de Endocrinología Pediátrica. 3ra. ed. Madrid: Ed. Mc Graw-Hill Interamericana; 2002. p. 32,557-64.
Pearce EN. Diagnosis and management of thyrotoxicosis. BMJ. 2009;332:1369- 73.
Acharya SH, Avenell A, Philip S. Radioiodine therapy (RAI) for Graves' disease (GD) and the effect on ophthalmopathy: a systematic review. Clinical Endocrinology (Oxford). 2008;69:943-50.
Mendoza C, Lacourt P. Orbitopatía de Graves en Pediatría. Rev Med Chile. 2015;143:1034-41.
Stan MN, Garrity JA, Bahn RS. The Evaluation and Treatment of Graves Ophthalmopathy. Med Clin North Am. 2012 March;96(2):311-28.
Terry FD, Reed LP. Tirotoxicosis. En: Kronember HM, Melmed SH, Polonsky KS, Reed LP. Williams Tratado de Endocrinología. 11na. ed. Barcelona: Elsevier; 2011. p. 341-84.
Stan MN, Garrity JA, Bahn RS. The evaluation and treatment of Graves´ophthalmopathy. Med Clin N Am. 2012;96(2):311-28.
Eguías Martínez F, Ríos Torres M, Capote Cabrera A. Orbitopatía asociada al tiroides. Manual de diagnóstico y tratamiento en Oftalmología. La Habana: Editorial Ciencias Médicas; 2009. p. 658-65.
Partomeu J. ¿La radioterapia en la oftalmopatía asociada al tiroides es o no beneficiosa? Arch Soc Esp Oftalmol. 2003;78(3):131-2.
Chao M, Jiawei X, Guoming W, Jianbin L, Wanxia L, Driedger A, et al. Radioiodine treatment for pediatric hyperthyroid Graves' disease. European Journal of Pediatrics. 2009;(168):1165-9.