González-León FD, Palacios-Cañizares EJ, Solís-Ayala E, Sanabria-Trujillo R, Hernández-Aguilar S, Pinto-Angulo VM, Infante-Montaño II

Language: Spanish
References: 17
Page: 137-142
PDF size: 194.00 Kb.

ABSTRACT

Introduction: Acute appendicitis is a common surgical pathology, its diagnosis is a clinical challenge, and its timely treatment prevents fatal complications, recent use of mean platelet volume (MPV) and platelet distribution width (PDW) can help in the diagnosis of this entity. Objectives: To determine if MPV and PDW have any relation with the diagnosis of acute appendicitis, when compared to their healthy control. Material and methods: Observational, retrospective study, from June to October 2016, in patients with acute appendicitis confirmed by histopathology and their healthy control with patients admitted for elective hernioplasty. Values of leukocytes, neutrophils, MPV and PDW were used for their analysis. Statistical analysis was performed with Student’s T for age and numbers of: leukocytes, net neutrophil count, platelets, MPV, PDW. In the appendicitis group Pearson correlation was performed with: Alvarado scale and appendicitis phase with respect to leukocytes, neutrophils, MPV and PDW. Results: Statistically significant differences were found in leukocytes, neutrophils, MPV and PDW between the two groups. Negative correlation was found between MPV and the degree of appendicitis; as well as positive correlation between PDW and degree of appendicitis. Conclusions: Despite the results, more studies are needed to establish the relationship between PDW and MPV with appendicitis.

REFERENCES

1. Saxena D, Tandon M, Gedam BS. Role of mean platelet volume (MPV) in diagnosis of acute appendicitis. Int J Biomedical Research 2015; 6(4): 235-7.

2. Tanrikulu CS, Tanrikulu Y, Sabuncuoglu MZ, Karamercan MA, Akkapulu N, Coskun F. Mean platelet volume and red cell distribution width as a diagnostic marker in acute appendicitis. Iran Red Crescent Med J 2014; 16(5): e10211.

3. Bilici S, Sekmenli T, Göksu M, Melek M, Avci V. Mean platelet volume in diagnosis of acute appendicitis in children. Afr Health Sci 2011; 11(3): 427-32.

4. Käser SA, Fankhauser G, Willi N, Maurer CA. C-reactive protein is superior to bilirubin for anticipation of perforation in acute appendicitis. Scand J Gastroenterol 2010; 45(7-8): 885-92.

5. D’Souza N, Karim D, Sunthareswaran R. Bilirubin; a diagnostic marker for appendicitis. Int J Surg 2013; 11(10): 1114-7.

6. Gutiérrez-Romero A, Gutiérrez-Grobe Y, Carrillo-Esper R. Volumen plaquetario medio: el tamaño sí importa. Med Int Mex 2013; 29(3): 307-10.

7. Uyanik B, Kavalci C, Arslan ED, Yilmaz F, Aslan O, Dede S et al. Role of mean platelet volume in diagnosis of childhood acute appendicitis. Emerg Med Int 2012; 2012: 823095.

8. Bozkurt S, Köse A, Erdogan S, Bozali GI, Ayrik C, Arpaci RB et al. MPV and other inflammatory markers in diagnosing acute appendicitis. J Pak Med Assoc 2015; 65(6): 637-41.

9. Dinc B, Oskay A, Dinc SE, Bas B, Tekin S. New parameter in diagnosis of acute appendicitis: platelet distribution width. World J Gastroenterol 2015; 21(6): 1821-6.

10. Yang SW, Cho SH, Kwon HS, Sohn IS, Hwang HS. Significance of the platelet distribution width as a severity marker for the development of preeclampsia. Eur J Obstet Gynecol Reprod Biol 2014; 175: 107-11.

11. Kucuk E, Kucuk I. Mean platelet volume is reduced in acute appendicitis. Turk J Emerg Med 2016; 15(1): 23-7.

12. Erdem H, Aktimue R, Centinkunar S, Reyhan E, Gokler C, Irkorucu O et al. Evaluation of mean platelet volume as a diagnostic biomarker in acute appendicitis. Int J Clin Exp Med 2015; 8(1): 1291-5.

13. Velázquez JV, Godínez C, Vázquez MA. Evaluación prospectiva de la escala de Alvarado en el diagnóstico de apendicitis aguda. Cir Gen 2010; 32(1): 17-23.

14. Flores-Nava G, Jamaica-Balderas ML, Landa-García RA, Parraguirre-Martínez S, Lavalle-Villalobos A. Apendicitis en la etapa pediátrica: correlación clínico-patológica. Bol Med Hosp Infant Mex 2005; 62(3): 195-201.

15. Kharbanda AB, Cosme Y, Liu K, Spitalnik SL, Dayan PS. Discriminative accuracy of novel and traditional biomarkers in children with suspected appendicitis adjusted for duration of abdominal pain. Acad Emerg Med 2011; 18(6): 567-74.

16. Tchebiner JZ, Nutman A, Boursi B, Shlomai A, Sella T, Wasserman A, Guzner-Gur H. Diagnostic and prognostic value of thrombocytosis in admitted medical patients. Am J Med Sci 2011; 342(5): 395-401.

17. Aydogan A, Akkucuk S, Arica S, Motor S, Karakus A, Ozkan OV et al. The analysis of mean platelet volume and platelet distribution width levels in appendicitis. Indian J Surg 2015; 77(Suppl 2): 495-500.