2017, Number 4
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Dermatología Cosmética, Médica y Quirúrgica 2017; 15 (4)
Subcorneal Pustular Dermatosis (Sneddon-Wilkinson Disease). A Review
Gómez-Ornelas E, Toussaint-Caire S, Arenas R
Language: Spanish
References: 30
Page: 272-276
PDF size: 144.88 Kb.
ABSTRACT
Subcorneal pustular dermatosis (Sneddon-Wilkinson disease) is
a rare neutrophilic dermatosis, usually with a benign and recurrent
course. Pathogenesis of this disease is not yet fully understood,
where there is hyperactivation of neutrophils, as a consequence
of some cytokines interactions. It presents clinically with
pustules mainly on trunk and intertriginous areas and rarely on
acral sites. Histologic sections show subcorneal collections of
neutrophils. Sometimes it is associated with other pathologies.
Treatment of choice is still dapsone, offering a rapid improvement,
however there are refractory cases that may require
more aggressive management.
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