2005, Number 1
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Rev Hosp Jua Mex 2005; 72 (1)
Presciption in aged patient: polypharmacy care and adverse reactions
Badillo BU
Language: Spanish
References: 17
Page: 18-22
PDF size: 71.24 Kb.
ABSTRACT
Adverse drug reactions are overall the most common form of iatrogenic illness, resulting in dangerous incapacitating and even life-threatening reactions in the elderly population. These adverse drug reactions make up 10% of all hospital admissions as a whole and represent billions of dollars in health-care expenses. This is a retrospective, longitudinal and descriptive study. The in-patient unit of the geriatric service, Hospital Reg 185 patients admitted to our in-patient unit over the period from March the 1st to August the 31st 2001. We made the diagnosis of polypharmacy in 27.5% of all admissions during the cited period of study, 78.4% of which were females and 21.6% males. With regard to the most common used drugs Cardiovascular agents represented the 76.4%, followed by those with activity at the gastrointestinal level (37.2%) and all classes of analgesics (35.2%), psychiatric drugs (33.3%), endocrinology drugs (23.5%), vitamins (17.6%), bronchodilators (9.8%) and agents with activity at the central nervous system (11.7%).
REFERENCES
Beizer, JL. Tratamiento farmacológico y con drogas en el anciano, en Timiras, P.S. Bases fisiológicas del envejecimiento y geriatría. Masson, 1997: 341-7.
Bressler, R. Adverse drug reactions, en Bressler, R. Geriatric Pharmacology. McGraw – Hill, 1993; 41-62.
Avorn J. Improving drug use in elderly patients: getting to the next level. JAMA 2001; 286: 2866.
Mintzer J, Burns A. Anticholinergic side-effects of drug in elderly people. J R Soc Med 2000; 93: 457.
Nies, AS. Principles of therapeutics, en Hardman, J.G. Goodman & Gilman´s The pharmacological basis of therapeutis, McGraw-Hill 9th ed, 1996; 43-61.
Sitar DS. Factores que influyen en la acción de los fármacos, en Page, CP, et al. Farmacología integrada. Mosby, 1998; 67-81.
Tariot PN, et al. Pharmacologic therapy for behavioral symptoms of Alzheimer´s disease. Clin Geriatr Med 2001;17: 359.
Semia, TS, et al. Geriatric dosage handbook, Lexi-comp, 6th ed, 2001.
Foster DF, et al. Alternative medicine use in older Americans. J Am Geriatr Soc 2000; 48: 1560.
Tune LE. Anticholinergic effects of medications in elderly patients. J Clin Psychiatry 2001; 62: 11.
Zhan C, et al. Potentially inappropriate medication use in the community-dwelling elderly: findings from the 1996 Medical Expenditure Panel –survey. JAMA 2001; 286: 2823.
Cohen JS. Avoiding adverse reactions. Effective lower-dose drug therapies for older patients. Geriatrics 2000; 55: 54.
Kane, RL. Farmacoterapia, en Kane RL. Geriatría clínica. McGraw-Hill, 4a ed, 1999; 331-60.
Beers MH. Explicit criteria for determining potentially inappropriate medication use by the elderly. An update. Arch Intern Med 1997; 157: 1531.
Hanlon JT, et al. Recent advances in geriatrics: drug related problems in the elderly. Ann Pharmacother 2000; 34: 360.
Díaz, AP. Yatrogenia y uso de fármacos; Herrero FJ. Historia de la gerocultura y evolución de la enfermería geriátrica y gerontológica, en Guillén F. Síndromes y cuidados en el paciente geriátrico. Masson, 1a ed. 2001; 239-436.
Rodríguez, GR. Farmacogeriatría, en Rodríguez GR, et al. Geriatría. McGraw-Hill, 1a ed. 2000; 259-68.