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2016, Number 4

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Rev Cubana Plant Med 2016; 21 (4)

Antitumor activity of curcumin associated with regulation of epigenetic mechanisms: implications for the Wnt/-catenin pathway

Cardona EAH, Uribe YDF, Cortés-Mancera FM

Language: Spanish
References: 71
Page: 1-22
PDF size: 805.48 Kb.


ABSTRACT

Introduction: Curcumin is the main bioactive polyphenolic compound in the plant Curcuma longa. This molecule has displayed antioxidant, anti-inflammatory and anticancer activity in various experimental models. Its beneficial effect on tumor cells has been associated with the regulation of epigenetic mechanisms, modulating various signaling pathways, among them the Wnt/-catenin pathway, which plays a fundamental role in cancer development.
Objectives: Describe the scientific progress achieved in the study of the anti-cancer activity of curcumin in relation to the modulation of epigenetic mechanisms and its implication for the Wnt/?-catenin pathway.
Methods: A systematic search was conducted in the databases PubMed, Google Scholar, Scopus and ScienceDirect, using the search terms 'curcumin', 'epigenetics', 'Wnt/?-catenin' and 'cancer'. Papers were included which had scientific relevance, had been published between 2001 and 2016, explored the inhibitory activity of curcumin on the epigenetic machinery and/or presented evidence of a regulatory effect on alterations in the Wnt/?-catenin pathway.
Results: Growing evidence was found in the literature associating curcumin with inhibition of the activity of the enzymes histone deacetylases, acetyltransferases and DNA methyltransferases, and therefore regulation of epigenetic alterations. This leads to re-expression of silenced genes in various cancer types, granting it antitumor activity associated with the regulation of signaling pathways. In this context, it has been proved that curcumin acts upon components of the Wnt/?-catenin pathway and even regulates their activity through demethylation of Wnt antagonists.
Conclusions: The paper discusses the potential chemopreventive effects of curcumin associated with restoration of epigenetic mechanisms and the Wnt/-catenin signaling pathway.


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