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Organo Oficial de la Sociedad Mexicana de Urología

2017, Number 4

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Rev Mex Urol 2017; 77 (4)

Premature ejaculation: A review of the pathology and treatment update

Carrillo-Córdova E, Rodríguez-Valle D, Rodriguez-Roble JA, Vitar-Sandoval J, Carrillo-Córdova JR, Obregón-Aguilar A

Language: Spanish
References: 58
Page: 328-335
PDF size: 310.40 Kb.


ABSTRACT

It is the most common male sexual disorder and can be classified as lifelong or acquired premature ejaculation, but the mechanism causing it is still unknown. Four events are identified in as normal response during sexual activity: 1) erection, 2) emission, 3) ejaculation, and 4) orgasm. When premature ejaculation produces few symptoms, treatment should be limited to psychosexual counseling. Several behavioral techniques have been shown to be beneficial in erectile dysfunction treatment, but they should not be considered first-line or sole treatment in patients with lifelong premature ejaculation. Those patients require drug-based management. Premature ejaculation is a frequent pathology with considerable psychosocial consequences. Treatment is directed at improving the duration of the sexual act and should be individualized for each patient.


REFERENCES

  1. Rowland DL, Patrick DL, Rothman M, et al. The psychological burden of premature ejaculation. J Urol 2007;177:1065- 70.

  2. Jannini EA, Ciocca G, Limocin E, Mollaioli D, et al. Premature ejaculation: old story, new insights. Fertil. Steril. 2015;104:1061-1073.

  3. Patrick DL, Althof SE, Pryor JL, et al. Premature ejaculation: an observational study of men and their partners. J Sex Med 2005;2:358-67.

  4. Waldinger MD. Relevance of an evidence-based ejaculation time cutoff point for neurobiological research of premature ejaculation. J. Comp. Neurol. 2005;493:46-50.

  5. McMahon CG, Althof SE, Waldinger MD, et al. An evidencebased definition of lifelong premature ejaculation: report of the International Society for Sexual Medicine (ISSM) ad hoc committee for the definition of premature ejaculation. J Sex Med 2008;5:1590-606.

  6. Waldinger MD. Premature ejaculation: state of the art. Urol Clin North Am 2007;34:591-9, vii-viii.

  7. Giuliano F. Neurophysiology of erection and ejaculation. J Sex Med 2011;8(Suppl. 4):310-315.

  8. Simoes Paco J, Jorge Pereira B. New therapeutic perspectives in premature ejaculation. Urology 2016;88:87-92.

  9. Porst H. An overview of pharmacotherapy in premature ejaculation. J Sex Med 2011;8(Suppl. 4):335-341.

  10. Giuliano F, Clement P. Pharmacology for the treatment of premature ejaculation. Pharmacol Rev 2012;64:621-644.

  11. Corona G, et al. Hypoprolactinemia: a new clinical syndrome in patients with sexual dysfunction. J Sex Med 2009;6:1457-1466.

  12. Sansone A, et al. Hormonal correlations of premature ejaculation. Endocrine 2015;49:333-338.

  13. Wespes EC, Eardley I, Giuliano F, et al. Guidelines on Male Sexual Dysfunction: erectile dysfunction and premature ejaculation. European Association of Urology, Arnhem, 2013.

  14. Olivier B, van Oorschot R, Waldinger MD. Serotonin, serotonergic receptors, selective serotonin reuptake inhibitors and sexual behaviour. Int. Clin. Psychopharmacol. 1998; 13(Suppl 6): S9–14.

  15. Giuliano F. 5-Hydroxytryptamine in premature ejaculation: opportunities for therapeutic intervention. Trends Neurosci. 2007;30:79-84.

  16. Waldinger MD. Premature ejaculation: definition and drug treatment. Drugs 2007;67:547-68.

  17. Waldinger MD, Zwinderman AH, Olivier B. On-demand treatment of premature ejaculation with clomipramine and paroxetine: a randomized, double-blind fixed-dose study with stopwatch assessment. Eur Urol 2004;46:510-6.

  18. Pryor JL, Althof SE, Steidle C, et al. Efficacy and tolerability of dapoxetine in treatment of premature ejaculation: an integrated analysis of two double-blind, randomised controlled trials. Lancet 2006;368:929-37.

  19. McMahon C, Kim SW, Park NC, et al. Treatment of premature ejaculation in the Asia-Pacific region: results from a phase III double-blind, parallel-group study of dapoxetine. J Sex Med 2010;7:256-68.

  20. Buvat J, Tesfaye F, Rothman M, et al. Dapoxetine for the treatment of premature ejaculation: results from a randomized, double-blind, placebo-controlled phase 3 trial in 22 countries. Eur Urol 2009;55:957-67.

  21. Gur S, Kadowitz PJ, Sikka SC, Current therapies for premature ejaculation. Drug Discov Today 2016;21:1147-1154.

  22. Leppert W. Tramadol as an analgesic for mild to moderate cancer pain. Pharmacol Rep 2009;61:978-92.

  23. Ogata J, Minami K, Uezono Y, et al. The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. Anesth. Analg. 2004; 98:1401-6.

  24. Bar-Or D, Salottolo KM, Orlando A, Winkler JV; Tramadol ODT Study Group. A randomized double-blind, placebocontrolled multicenter study to evaluate the efficacy and safety of two doses of the tramadol orally disintegrating tablet for the treatment of premature ejaculation within less than 2 minutes. Eur Urol 2012;61:736-43.

  25. Kirby EW, Carson CC, Coward RM. Tramadol for the management of premature ejaculation: a timely systematic review. Int J Impot Res 2015;27:121-7.

  26. Takeshita J, Litzinger MH. Serotonin syndrome associated with tramadol. Prim Care Companion J Clin Psychiatry 2009;11:273.

  27. Jannini EA, McMahon C, Chen J, Aversa A, Perelman M. The controversial role of phosphodiesterase type 5 inhibitors in the treatment of premature ejaculation. J Sex Med 2011;8:2135-2143.

  28. McMahon CG, McMahon CN, Leow LJ, Winestock CG. Efficacy of type-5 phosphodiesterase inhibitors in the drug treatment of premature ejaculation: a systematic review. Br J Urol 2006;98:259-72.

  29. Debruyne FM. Alpha blockers: are all created equal? Urology 2000;56(5 Suppl 1):20–2.

  30. Hisasue SI, Furuya R, Itoh N, Kobayashi K, Furuya S, Tsukamoto T. Ejaculatory disorder caused by alpha-1 adrenoceptor antagonists is not retrograde ejaculation but a loss of seminal emission. Int. J Urol 2006;13:1311-6.

  31. Akin Y, Gulmez H, Ates M, Bozkurt A, Nuhoglu B. Comparison of alpha blockers in treatment of premature ejaculation: a pilot clinical trial. Iran. Red Crescent Med J 2013;15:e13805.

  32. Debruyne FM, Van der Poel HG. Clinical experience in Europe with uroselective alpha 1-antagonists. Eur Urol 1999;36(Suppl 1):54-58.

  33. Gillman PK. Tricyclic antidepressant pharmacology and therapeutic drug interactions updated. Br J Pharmacol 2007;151:737-48.

  34. Kim SC, Seo KK. Efficacy and safety of fluoxetine, sertraline and clomipramine in patients with premature ejaculation: a double-blind, placebo controlled study. J Urol 1998;159:425-7.

  35. Xin ZC, Chung WS, Choi YD, Seong DH, Choi YJ, Choi HK. Penile sensitivity in patients with primary premature ejaculation. J Urol 1996;156:979-81.

  36. Guyton and Hall Textbook of Medical Physiology. Philadelphia: Elsevier, 2016.

  37. Yagiela JA. Vasoconstrictor agents for local anesthesia. Anesth Prog 1995;42:116-20.

  38. Atikeler MK, Gecit I, Senol FA. Optimumusage of prilocainelidocaine cream in premature ejaculation. Andrologia 2002;34:356-9.

  39. Busato W, Galindo CC. Topical anaesthetic use for treating premature ejaculation: a double-blind, randomized, placebo-controlled study. BJU Int 2004;93:1018-21.

  40. Henry R, Morales A, Wyllie MG. TEMPE: topical eutecticlike mixture for premature ejaculation. Expert Opin. Drug Deliv. 2008;5:251-61.

  41. Gilbert R. Promescent. Absorption Pharmaceuticals, LLC (Online), 2015. (Cited 29 Dic 2016.) Available from URL: https://www.promescent.com/about-promescent/ promescent-and-psd-502.

  42. Choi HK, Jung GW, Moon KH, et al. Clinical study of SScream in patients with lifelong premature ejaculation. Urology 2000;55:257-61.

  43. Yang DY, Ko K, Lee WK, et al. Urologist's practice patterns including surgical treatment in the management of premature ejaculation: A Korean nationwide survey. World J Mens Health 2013;31:226-31.

  44. Zhang GX, Yu LP, Bai WJ, et al. Selective resection of dorsal nerves of penis for premature ejaculation. Int J Androl 2012;35:873-9.

  45. Basal S, Goktas S, Ergin A, et al. A novel treatment modality in patients with premature ejaculation resistant to conventional methods: the neuromodulation of dorsal penile nerves by pulsed radiofrequency. J Androl 2010;31:126-30.

  46. David-Prologo J, Snyder LL, Cherullo E, et al. Percutaneous CT-guided cryoablation of the dorsal penile nerve for treatment of symptomatic premature ejaculation. J Vasc Interv Radiol 2013;24:214-9.

  47. Kim JJ, Kwak TI, Jeon BG, et al. Effects of glans penis augmentation using hyaluronic acid gel for premature ejaculation. Int J Impot Res 2004;16:547-51.

  48. Kwak TI, Jin MH, Kim JJ, et al. Long-term effects of glans penis augmentation using injectable hyaluronic acid gel for premature ejaculation. Int J Impot Res 2008;20:425-8.

  49. Moon du G, Kwak TI, Kim JJ. Glans penis augmentation using hyaluronic acid gel as an injectable filler. World J Mens Health 2015;33:50-61.

  50. Tuncali D, Bingul F, Talim B, et al. Histologic characteristics of the human prepuce pertaining to its clinical behavior as a dual graft. Ann Plast Surg 2005;54:191-5.

  51. Tian Y, Liu W, Wang JZ, et al. Effects of circumcision on male sexual functions: a systematic review and metaanalysis. Asian J Androl 2013;15:662-6.

  52. Cortes-Gonzalez JR, Arratia-Maqueo JA, Martinez-Montelongo R, et al. Does circumcision affect male’s perception of sexual satisfaction? Arch Esp Urol 2009;62:733-6.

  53. Metz ME, Pryor JL, Nesvacil LJ, Abuzzahab F Sr, Koznar J. Premature ejaculation: a psychophysiological review. J Sex Marital Ther 1997;23:3-23.

  54. De Amicis LA, Goldberg DC, LoPiccolo J, Friedman J, Davies L. Clinical follow-up of couples treated for sexual dysfunction. Arch Sex Behav 1985;14:467-89.

  55. Perelman MA. A new combination treatment for premature ejaculation: a sex therapist’s perspective. J Sex Med 2006;3:1004-12.

  56. Althof SE. Psychological approaches to the treatment of rapid ejaculation. The JMHG 2006;3:180-6.

  57. Melnik T, Althof S, Atallah AN, Puga MEDS, Glina S, Riera R. Psychosocial interventions for premature ejaculation. Cochrane Database Syst Rev 2011;(8):CD008195.

  58. Pastore AL, Palleschi G, Leto A, Pacini L, Iori F, Leonardo C, et al. A prospective randomized study to compare pelvic floor rehabilitation and dapoxetine for treatment of lifelong premature ejaculation. Int J Androl 2012;35:528-33.




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