medigraphic.com
ISSN 2007-2783 (Print)
Órgano Oficial del Instituto Científico Pfizer

2017, Number 2

<< Back

Residente 2017; 12 (2)

MicroARNs (miARNs) como biomarcadores moleculares para el diagnóstico, pronóstico y predicción de la respuesta terapéutica en enfermedades reumáticas

Valdovinos-Maravilla JP, Romero-Morán MF, Rodríguez-González G, Dávalos-Rodríguez IP, De Alba-Razo A, Aceves-Aceves MA, Villalobos-Mendoza JJ, Hernández-Preciado MR, Morán-Moguel MC

Language: Spanish
References: 18
Page: 67-71
PDF size: 289.61 Kb.


ABSTRACT

Systemic autoimmune rheumatic diseases (SRD) are characterized by chronical joints inflammation and other tissues of the body. In recent years there has been a great progress in characterizing the genetic bases that predispose to develop this group of diseases. MicroRNAs (miRNAs) have emerged as molecular biomarkers for the diagnosis, prognosis and prediction of therapeutic response in different pathologies. The miRNAs are small molecules of a single strand of non-coding RNA of 21-23 nucleotides that are expressed endogenously in multicellular organisms and whose known function is the control of gene expression, mainly by repression at the post-transcriptional level. Each miRNA is estimated to regulate up to two hundred genes. The purpose of this article pretends to provide an update of the information on the importance and utility of miRNAs as molecular biomarkers in the diagnosis, prognosis and therapeutic response in systemic lupus erythematosus (SLE), rheumatoid arthritis (RA) and psoriatic arthritis (PA).


REFERENCES

  1. Rico-Rosillo MG, Vega-Robledo GB, Oliva-Rico D. Importancia de los microARN en el diagnóstico y desarrollo de enfermedades. Rev Med Inst Mex Seguro Soc. 2014; 52 (3): 302-307.

  2. Lugo-Trampe A, Trujillo-Murillo KC. MicroRNAs: reguladores clave de la expresión génica. Med Univer. 2009; 11 (44): 187-192.

  3. Li Y, Qiu C, Tu J, Geng B, Yang J, Jiang T et al. HMDD v2.0: a database for experimentally supported human microRNA and disease associations. Nucleic Acids Res. 2014; 42 (Database issue): D1070-4.

  4. Wang G, Tam LS, Li EK, Kwan BC, Chow KM, Luk CC et al. Serum and urinary free microRNA level in patients with systemic lupus erythematosus. Lupus. 2011; 20 (5): 493-500.

  5. Chauhan SK, Singh VV, Rai R, Rai M, Rai G. Differential microRNA profile and post-transcriptional regulation exist in systemic lupus erythematosus patients with distinct autoantibody specificities. J Clin Immunol. 2014; 34 (4): 491-503.

  6. Vicente R, Noël D, Pers YM, Apparailly F, Jorgensen C. Deregulation and therapeutic potential of microRNAs in arthritic diseases. Nat Rev Rheumatol. 2016; 12 (4): 211-220.

  7. Mishra PJ, Humeniuk R, Mishra PJ, Longo-Sorbello GS, Banerjee D, Bertino JR. A miR-24 microRNA binding-site polymorphism in dihydrofolate reductase gene leads to methotrexate resistance. Proc Natl Acad Sci U S A. 2007; 104 (33): 13513-13518.

  8. Hausser J, Zavolan M. Identification and consequences of miRNA-target interactions--beyond repression of gene expression. Nat Rev Genet. 2014; 15 (9): 599-612.

  9. Ospelt C. Epigenetic biomarkers in rheumatology - the future? Swiss Med Wkly. 2016; 146: w14312.

  10. Churov AV, Oleinik EK, Knip M. MicroRNAs in rheumatoid arthritis: altered expression and diagnostic potential. Autoimmun Rev. 2015; 14 (11): 1029-1037.

  11. Kurowska-Stolarska M, Alivernini S, Ballantine LE, Asquith DL, Millar NL, Gilchrist DS et al. MicroRNA-155 as a proinflammatory regulator in clinical and experimental arthritis. Proc Natl Acad Sci U S A. 2011; 108 (27): 11193-11198.

  12. Gibson G, Asahara H. microRNAs and cartilage. J Orthop Res. 2013; 31 (9): 1333-1344.

  13. Stanczyk J, Ospelt C, Karouzakis E, Filer A, Raza K, Kolling C et al. Altered expression of microRNA-203 in rheumatoid arthritis synovial fibroblasts and its role in fibroblast activation. Arthritis Rheum. 2011; 63 (2): 373-381.

  14. Tavasolian F, Abdollahi E, Rezaei R, Momtazi-Borojeni AA, Henrotin Y, Sahebkar A. Altered expression of MicroRNAs in rheumatoid arthritis. J Cell Biochem. 2017 Jun 9. doi: 10.1002/jcb.26205.

  15. Pauley KM, Cha S, Chan EK. MicroRNA in autoimmunity and autoimmune diseases. J Autoimmun. 2009; 32 (3-4): 189-194.

  16. Ciancio G, Ferracin M, Saccenti E, Bagnari V, Farina I, Furini F et al. Characterisation of peripheral blood mononuclear cell microRNA in early onset psoriatic arthritis. Clin Exp Rheumatol. 2017; 35 (1): 113-121.

  17. Hamam D, Ali D, Kassem M, Aldahmash A, Alajez NM. microRNAs as regulators of adipogenic differentiation of mesenchymal stem cells. Stem Cells Dev. 2015; 24 (4): 417-425.

  18. Paek SY, Han L, Weiland M, Lu CJ, McKinnon K, Zhou L et al. Emerging biomarkers in psoriatic arthritis. IUBMB Life. 2015; 67 (12): 923-927.




2020     |     www.medigraphic.com