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Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán

2017, Number 3

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Rev Invest Clin 2017; 69 (3)

Non-Nutritive Sweeteners: Evidence on their Association with Metabolic Diseases and Potential Effects on Glucose Metabolism and Appetite

Romo-Romo A, Aguilar-Salinas CA, Gómez-Díaz RA, Brito-Córdova GX, Gómez-Velasco DV, López-Rocha MJ, Almeda-Valdés P

Language: English
References: 64
Page: 129-138
PDF size: 150.02 Kb.


ABSTRACT

There is ongoing debate concerning non-nutritive sweeteners, their usage, and their effects on metabolism. The association between non-nutritive sweeteners consumption, development of metabolic diseases, and changes in appetite-regulating hormones is not clear. The aim of this article is to present an overview of non-nutritive sweeteners and to examine the scientific evidence of their effects on glucose metabolism and appetite-regulating hormones. Some observational studies suggest an association between non-nutritive sweeteners consumption and development of metabolic diseases; however, adiposity is a confounder frequently found in these studies. Results of the available clinical trials are heterogeneous and not comparable because of major differences between them. Future controlled studies evaluating specific non-nutritive sweeteners, with an appropriate sample size, including a uniform study group, with sufficient exposure time, and considering adjustment for confounder variables, such as anthropometric characteristics, previous consumption of non-nutritive sweeteners, and coexistence of significant metabolic comorbidities, are needed.


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