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2017, Number 4

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Ann Hepatol 2017; 16 (4)

Occult Hepatitis C Infection Among Hemodialysis Patients: A Prevalence Study

Naghdi R, Ranjbar M, Bokharaei-Salim F, Keyvani H, Savaj S, Ossareh S, Shirali A, Mohammad-Alizadeh AH

Language: English
References: 19
Page: 510-513
PDF size: 165.91 Kb.


ABSTRACT

Introduction and aim. Occult hepatitis C infection (OHCI) is the presence of HCV-RNA in the liver or peripheral blood mononuclear cells (PBMC) accompanying with negative serologic results. The aim of this study was to evaluate the prevalence of OHCI among Iranian chronic hemodialysis (HD) patients. Material and methods. In this cross sectional study 200 chronic HD patients with negative HCV antibody enrolled the study. Blood sample of patients were obtained, followed by Polymerase Chain reaction (PCR) testing for detection of HCV RNA. Patients with positive serum HCV RNA were considered as manifest hepatitis C infection (MHCI). However, patients with negative serum HCV RNA underwent further tests on PBMCs for detection of OHCI. Results. Serum HCV RNA was positive in 2 (1%) patients whom considered as MHCI, and 6 (3.03%) patients had positive PBMC HCV RNA. Conclusion. In conclusion, chronic HD patients have been considered as a high risk group for hepatitis C infection. The results of this study suggest that these patients are also at risk for OHCI. Furthermore, evaluating PBMCs to detect HCV RNA would be a sensitive diagnostic method to find OHCI patients.


REFERENCES

  1. Jiang J, Cun W, Wu X, Shi Q, Tang H, Luo G. Hepatitis C Virus Attachment Mediated by Apolipoprotein E Binding to Cell Surface Heparan Sulfate. J Virol 2012; 86: 7256-67.

  2. Baid-Agrawal S, Pascual M, Moradpour D, Frei U, Tolkoff- Rubin N. Hepatitis C virus infection in haemodialysis and kidney transplant patients. Rev Med Virol 2008; 18: 97-115.

  3. Pol S, Vallet-Pichard A, Corouge M, Mallet VO. Hepatitis C: epidemiology, diagnosis, natural history and therapy. Contrib Nephrol 2012; 176: 1-9.

  4. Alavian SM. Diabetes, renal failure and hepatitis C infection: The puzzle should be attended more in future. Nephro Urol Mon 2011; 3: 153-4.

  5. Barril G, Castillo I, Arenas MD, Espinosa M, Garcia-Valdecasas J, Garcia-Fernandez N, González-Parra E, et al. Occult hepatitis C virus infection among hemodialysis patients. J Am Soc Nephrol 2008; 19: 2288-92.

  6. Pereira BJ, Levey AS. Hepatitis C virus infection in dialysis and renal transplantation. Kidney Int 1997; 51: 981-99.

  7. Zylberberg H, Carnot F, Mamzer MF, Blancho G, Legendre C, Pol S. Hepatitis C virus-related fibrosing cholestatic hepatitis after renal transplantation. Transplantation 1997; 63: 158-60.

  8. Ozer-Etik D, Ocal S, Boyacioglu AS. Hepatitis C infection in hemodialysis patients: A review. World J Hepatol 2015; 7: 885-95.

  9. Oesterreicher C, Hammer J, Koch U, Pfeffel F, Sunder-Plassmann G, Petermann D, Müller C. HBV and HCV genome in peripheral blood mononuclear cells in patients undergoing chronic hemodialysis. Kidney Int 1995; 48: 1967-71.

  10. Castillo I, Pardo M, Bartolomé J, Ortiz-Movilla N, Rodríguez-Ińigo E, de Lucas S, Salas C, et al. Occult hepatitis C virus infection in patients in whom the etiology of persistently abnormal results of liver-function tests is unknown. J Infect Dis 2004; 189: 7-14.

  11. Delarocque-Astagneau E, Baffoy N, Thiers V, Simon N, de Valk H, Laperche S, Couroucé AM, et al. Outbreak of hepatitis C virus infection in a hemodialysis unit: potential transmission by the hemodialysis machine? Infect Control Hosp Epidemiol 2002; 23: 328-34.

  12. Taherkhani R, Farshadpour F. Epidemiology of hepatitis C virus in Iran. World J Gastroenterol 2015; 21: 10790-810.

  13. Jain P, Nijhawan S. Occult hepatitis C virus infection is more common than hepatitis B infection in maintenance hemodialysis patients. World J Gastroenterol 2008; 14: 2288-9.

  14. Schneeberger PM, Keur I, van der Vliet W, van Hoek K, Boswijk H, van Loon AM, van Dijk WC, et al. Hepatitis C virus infections in dialysis centers in The Netherlands: a national survey by serological and molecular methods. J Clin Microbiol 1998; 36: 1711-5.

  15. El-shishtawy S, Sherif N, Abdallh E, Kamel L, Shemis M, Saleem AA, Abdalla H, et al. Occult Hepatitis C Virus Infection in Hemodialysis Patients; Single Center Study. Electron Physician 2015; 7: 1619-25.

  16. Bokharaei-Salim F, Keyvani H, Monavari SH, Alavian SM, Madjd Z, Toosi MN, Mohammad-Alizadeh AH. Occult Hepatitis C Virus Infection in Iranian Patients With Cryptogenic Liver Disease. J Med Virol 2011; 83: 989-95.

  17. Eslamifar A, Ramezani A, Ehteram H, Razeghi E, Ahmadi F, Amini M, Banifazl M, et al. Occult hepatitis C virus infection in Iranian hemodialysis patients. J Nephropathol 2015; 4: 116-20.

  18. Baid-Agrawal S, Schindler R, Reinke P, Staedtler A, Rimpler S, Malik B, Frei U, et al. Prevalence of occult hepatitis C infection in chronic hemodialysis and kidney transplant patients. J Hepatol 2014; 60: 928-33.

  19. Abdelrahim SS, Khairy R, Esmail MA, Ragab M, Abdel-Hamid M, Abdelwahab SF. Occult Hepatitis C Virus Infection among Egyptian Hemodialysis Patients. J Med Virol 2016; 88: 1388-93.




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