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2016, Number 3

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Rev Educ Bioquimica 2016; 35 (3)

La paradoja del uso de antioxidantes durante el tratamiento contra el cáncer: ¿proteger al organismo de los efectos tóxicos de los antineoplásicos disminuiría la eficacia farmacológica para evitar el desarrollo del cáncer?

Guerrero ML, Maldonado VM, Calderón SJV

Language: Spanish
References: 67
Page: 71-88
PDF size: 435.46 Kb.


ABSTRACT

Cancer is a disease that involves the transformation of normal cells to neoplastic cells. The hallmarks of neoplastic cells are rapid cell proliferation and uncontrolled cell growth. Antineoplastic drugs used in cancer treatment induce apoptosis in neoplastic cells; however they are not specific for neoplastic cells and cause toxic effects in non-neoplastic cells. Oxidative damage maybe induced by antineoplastic treatment, this damage could be involved in the toxicity of treatment, so antioxidants use have been proposed to reduce this toxicity. However antioxidant could decrease pharmacological effect of the antineoplastic because oxidative stress might participate in the mechanisms of action of antineoplastic. In this review we discute about a) antioneoplastic action mechanisms, b) involvement of oxidative stress in apoptosis induced by treatment, c) oxidative damage generated by antineoplastic treatment, and d) antioxidants co-treatment to reduce oxidative damage without inhibit antineoplastic-induced apoptosis.


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