medigraphic.com

2016, Number 1

<< Back Next >>

Rev Educ Bioquimica 2016; 35 (1)

La n6-metiladenina: una potencial marca de regulación epigenética en eucariontes

Murillo OAR, Rodríguez-Aguilera JR

Language: Spanish
References: 14
Page: 11-17
PDF size: 550.46 Kb.


ABSTRACT

The modified nucleotide N6-methyladenine in DNA (6mA), -which was described originally as a mechanism of protection for the bacterial DNA against the restriction enzymes- recently it has become important because three reports in eukaryotic organisms, the fruit fly Drosophila melanogaster, the worm Caenorhabditis elegans and the green algae Chlamydomonas reinhardtii, identified variations in the levels of this modification as well as in the enzymes that establish and remove it. These variations correlate with the functional alterations of these three organisms and therefore, the 6mA reappears as a potential epigenetic mark.


REFERENCES

  1. Recillas-Targa F (2014) Interdependency between genetic and epigenetic regulatory defects in cancer. Meth Mol Biol 1165: 33-52.

  2. Griffiths AJF, Wessler SR, Lewontin RC, Carroll SB (2008) Genética, 9ª Ed. Mc Graw Hill. España.

  3. Bhutani N, Burns DM, Blau HM (2011) DNA demethylation dynamics. Cell 146: 866-872.

  4. Arber W, Dussoix D (1962) Host specificity of DNA produced by Escherichia coli. I. Host controlled modification of bacteriophage lambda. J Mol Biol 5: 18-36.

  5. van Steensel lab: DamID info. Netherlands Cancer Institute. [Información en Intenet] 2013 [acceso 31 de Julio de 2015] Disponible en http://research.nki.nl/vansteensellab/ DamID_FAQ.htm

  6. Greil F, Moorman C, van Steensel B (2006) DamID: mapping of in vivo protein-genome interactions using tethered DNA adenine methyltransferase. Meth of Enzimol 410: 342- 357.

  7. Zhang G, Huang H, Liu D, Cheng Y, Liu X, Zhang W, Yin R, Zhang D, Zhang P, Liu J, Li C, Liu B, Luo Y, Zhu Y, Zhang N, He S, He C, Wang H, Chen D (2015) N(6)-methyladenine DNA modification in Drosophila. Cell 161: 893-906.

  8. Greer EL, Blanco MA, Gu L, Sendinc E, Liu J, Aristizabal-Corrales D, Hsu CH, Aravind L, He C, Shi Y (2015) DNA Methylation on N(6)- Adenine in C elegans. Cell 161: 868-878.

  9. Fu Y, Luo GZ, Chen K, Deng X, Yu M, Han D, Hao Z, Liu J, Lu X, Dore LC, Weng X, Ji Q, Mets L, He C (2015) N(6)-methyldeoxyadenosine marks active transcription start sites in chlamydomonas. Cell 161: 879-892.

  10. Heyn H, Esteller M (2015) An adenine Code for DNA: A Second Life for N6-methyladenine. Cell 161:710-713.

  11. Luo GZ, Blanco MA, Greer EL, He C, Shi Y (2015)DNA N(6)-methyladenine: a new epigenetic mark in eukaryotes? Nature reviews. Mol Cell Biol 16:705-710.

  12. Sun Q, Huang S, Wang X, Zhu Y, Chen Z, Chen D (2015) N(6)-methyladenine functions as a potential epigenetic mark in eukaryotes. Bioassays 37:1155-1162.

  13. Summerer D (2015) N(6)-Methyladenine: A Potential Epigenetic Mark in Eukaryotic Genomes. Angew Chem Int Ed Engl 54: 10714-10716.

  14. Huang S, Chen D (2015) N6-methyladenine: a potential epigenetic mark I eukaryotes. Oncotarget 6:15744-15745.




2020     |     www.medigraphic.com