Rodríguez MK, Reyes MIM, Flores SRM, Méndez VJ

Language: Spanish
References: 0
Page: 1-13
PDF size: 154.80 Kb.

ABSTRACT

Introduction: in vitro fertilization with embryo transfer is the most used infertility treatment in the assisted reproductive techniques.
Objective: to identify the clinical and therapeutic factors affecting the quality of embryos obtained from in vitro fertilization in infertile patients undergoing this technique.
Methods: a retrospective longitudinal study was conducted to determine the influence of clinical and therapeutic factors such as maternal age, dosage of folliclestimulating hormone in previous cycle, number of aspired oocytes in the in vitro fertilization cycle, the analogue of the gonadotropin-releasing hormone used and the cause of infertility on the quality of cultured embryos.
Results: of 419 studied couples, good quality embryo trios were obtained in 60.86 % of the sample. There were statistically significant differences between the patients with good and with bad embryo quality in terms of age (p= 0.029), number of aspired ovocytes (p< 0.0001) and cause of infertility (p< 0.002). In multivariate analysis, the unknown cause of infertility (odds ratio: 0.13 [95 % CI: 0.036-0.49]; p= 0.002) and the age (odds ratio: 0.96 [95 % CI: 0.81-0.99]; p= 0.042) were associated to obtaining low quality embryos whereas the highest number of aspired ovocytes was associated to good quality embryos (odds ratio: 1.08 [95 % CI: 1.03-1.13]; p= 0.002).
Conclusions: a higher number of aspired oocytes encourages obtaining good quality embryos whereas infertility of unknown cause and older age reduce it.