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2015, Number 2

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Rev Educ Bioquimica 2015; 34 (2)

El papel de las plaquetas en enfermedades autoinmunes

Ramirez-Cruz NE, Ilescas I, Gallegos B, Solorzano C, Perez Y, Hernández CP

Language: Spanish
References: 48
Page: 49-58
PDF size: 524.96 Kb.


ABSTRACT

Platelets are small anucleate cells derived from megakaryocytes in the bone marrow, play a vital role in the normal hemostatic response to endothelial damage and are key elements in the stroke and heart attack. Platelets play an important role in the modulation of innate immune response because they possess rudimentary activity antibacterial and phagocytic, and in adaptive immune responses. In addition that contain proinflammatory cytokines such as IL-1, in this way modulates the immune response and inflammatory. In rheumatoid arthritis platelets and platelet-derived microparticles can accumulate in the joints of rheumatoid arthritis patients, plus platelets can be essential to the progression of inflammatory arthritis. In systemic lupus erythematosus, there is an increased platelet reactivity and increased serum CD40L in patients with systemic lupus erythematosus. In systemic sclerosis, platelets are activated in this disease. This review presents an overview on the role of platelets in autoinmune diseases.


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