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2017, Number 5

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Rev Fac Med UNAM 2017; 60 (5)

Thymic regulatory T cells: origins, role and their importance in illnes and health

Chávez SFR, Rojas-Lemus M, Fortoul GTI, Tenorio ZEP

Language: Spanish
References: 24
Page: 36-44
PDF size: 610.61 Kb.


ABSTRACT

Regulatory T cells (Tregs) are key mediators of the immune response; they have a collection of suppressive mechanisms that allow them to control both, self-reactive lymphocytes and conventional T cell clones. Although this population corresponds only to 5-10% of the CD4 T cells compartment, their absence has been related to the development of autoimmunity, the worsening of proinflammatory conditions and even abortions. Tregs can originate at the thymus or the periphery, however thymic Tregs are characterized by their stable phenotype and their capacity to recognize auto-antigens. In this review, we aim to provide a general understanding of the characteristics of Tregs and their importance within pathologies with a special focus on thymic Tregs; we offer herein a general picture of T cell ontogeny emphasizing the mechanisms and molecules involved in Treg generation.


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