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2017, Number 1

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RCAN 2017; 27 (1)

Serum prealbumin in the recognition of hospital manutrition

Meléndez MY, Soto MJ, Barreto PJ, Mora DI

Language: Spanish
References: 61
Page: 98-111
PDF size: 550.21 Kb.


ABSTRACT

Rationale: Prealbumin (PAB) is a hepatic secretory protein used in the nutritional assessment exercises due to its shortened halflife and ease of analytical determination. PAB might identify those malnourished patients at risk of complications and death after elective surgery. Objective: To assess the behavior of PAB as marker of hospital malnutrition. Study design: Prospective, longitudinal, analytical. Study serie: Eighty-seven patients (Males: 55.1%; Ages ≥ 60 years: 41.3%; Length of stay: 14.9 ± 22.1 days; Mortality rate: 14.9%) assisted at the “Hermanos Ameijeiras” Clinical Surgical Hospital (Havana Citym, Cuba) between September 2014 and December 2015 (both included); and were subjected to nutritional intervention. Material and method: Nature and strength of associations between serum PAB, on one hand, and hospital length of stay and mortality, on the other; were assessed. Resultados: Average PAB on admission was 0.11 ± 0.07 g.L-1. Eighty-two-point-seven percent of patients presented with PAB ‹ 0.2 g.L-1. Basal PAB values were independent from Body Mass Index (BMI) and score assigned by means of the Subjective Global Assessment (SGA). PAB was also independent from hospital length of stay and mortality. Basal PAB values increased 3 and 7 days after nutritional intervention. Changes in PAB might be explained given the reduction of systemic inflammatory response and hypercatabolism. Conclusiones: Decreased PAB might distinguish those patients signaled for nutritional intervention.


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